pcolcea procollagen C-endopeptidase enhancer a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pcolceaprovided by ZNC
Official Full Name: procollagen C-endopeptidase enhancer aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041014-370
See related: Ensembl:ENSDARG00000056913 AllianceGenome:ZFIN:ZDB-GENE-041014-370
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: polce; fj16f06; zC237L4.5; wu:fj16f06; zgc:136636; si:ch211-237l4.5
Summary: Predicted to be located in extracellular region. Orthologous to human PCOLCE (procollagen C-endopeptidase enhancer). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 10

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (22789070..22803740, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (22819881..22834288, complement)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables collagen binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptidase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: procollagen C-endopeptidase enhancer a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030181.3 → NP_001025352.2 procollagen C-endopeptidase enhancer a precursor

See identical proteins and their annotated locations for NP_001025352.2

Status: VALIDATED

Source sequence(s)

AL807389

UniProtKB/TrEMBL

A0A8M1N7B6, Q1ECX8

Related

ENSDARP00000151294.1, ENSDART00000187968.1

Conserved Domains (2) summary

cd00041
Location:157 → 270

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd03576
Location:355 → 479

NTR_PCOLCE; NTR domain, PCOLCE subfamily; Procollagen C-endopeptidase enhancers (PCOLCEs) are extracellular matrix proteins that enhance the activity of procollagen C-proteases, by binding to the procollagen I C-peptide. They contain a C-terminal NTR domain, which ...