pik3r4 phosphoinositide-3-kinase, regulatory subunit 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pik3r4provided by ZNC
Official Full Name: phosphoinositide-3-kinase, regulatory subunit 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-050309-84
See related: Ensembl:ENSDARG00000060469 AllianceGenome:ZFIN:ZDB-GENE-050309-84
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: vps15; im:7148788
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in late endosome to vacuole transport; pexophagy; and protein targeting to vacuole. Predicted to act upstream of or within macroautophagy and protein phosphorylation. Predicted to be part of phosphatidylinositol 3-kinase complex, class III, type I and phosphatidylinositol 3-kinase complex, class III, type II. Predicted to be active in late endosome and nucleus-vacuole junction. Is expressed in head; pronephric duct; and skeletal muscle. Orthologous to human PIK3R4 (phosphoinositide-3-kinase regulatory subunit 4). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (36721230..36749074, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (36767346..36794581, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

VPS15 regulates ciliary processes in zebrafish.
Title: A mutation in VPS15 (PIK3R4) causes a ciliopathy and affects IFT20 release from the cis-Golgi.

Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

fj26f11.y1 (e-PCR)
- UniSTS:198920

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within late endosome to vacuole transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within macroautophagy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphoinositide 3-kinase regulatory subunit 4

XP_001922676.1

EC 2.7.11.1

XP_005158356.1

EC 2.7.11.1

XP_021322650.1

EC 2.7.11.1

XP_068070300.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007127.7 Reference GRCz11 Primary Assembly

Range

36721230..36749074 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068214199.1 → XP_068070300.1 phosphoinositide 3-kinase regulatory subunit 4 isoform X1
XM_005158299.5 → XP_005158356.1 phosphoinositide 3-kinase regulatory subunit 4 isoform X3

UniProtKB/TrEMBL

A0A8M2B4N3, E9QFS6

Related

ENSDARP00000115670.1, ENSDART00000133310.3

Conserved Domains (7) summary

smart00320
Location:1309 → 1340

WD40; WD40 repeats

smart00220
Location:26 → 304

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG2319
Location:969 → 1340

WD40; WD40 repeat [General function prediction only]

cd13980
Location:25 → 315

STKc_Vps15; Catalytic domain of the Serine/Threonine kinase, Vacuolar protein sorting-associated protein 15

sd00044
Location:543 → 570

HEAT; HEAT repeat [structural motif]

sd00039
Location:1024 → 1069

7WD40; WD40 repeat [structural motif]

cl02567
Location:961 → 1247

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_001922641.7 → XP_001922676.1 phosphoinositide 3-kinase regulatory subunit 4 isoform X1

UniProtKB/TrEMBL

A0A8M1QHR9

Conserved Domains (7) summary

smart00320
Location:1353 → 1384

WD40; WD40 repeats

smart00220
Location:26 → 304

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG2319
Location:1013 → 1384

WD40; WD40 repeat [General function prediction only]

cd13980
Location:25 → 315

STKc_Vps15; Catalytic domain of the Serine/Threonine kinase, Vacuolar protein sorting-associated protein 15

sd00044
Location:543 → 570

HEAT; HEAT repeat [structural motif]

sd00039
Location:1068 → 1113

7WD40; WD40 repeat [structural motif]

cl02567
Location:1005 → 1291

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_021466975.2 → XP_021322650.1 phosphoinositide 3-kinase regulatory subunit 4 isoform X2

UniProtKB/TrEMBL

A0A8M9PN73

Related

ENSDARP00000079663.5, ENSDART00000085228.6

Conserved Domains (5) summary

smart00320
Location:1316 → 1347

WD40; WD40 repeats

cd13980
Location:25 → 315

STKc_Vps15; Catalytic domain of the Serine/Threonine kinase, Vacuolar protein sorting-associated protein 15

sd00044
Location:543 → 570

HEAT; HEAT repeat [structural motif]

sd00039
Location:1031 → 1076

7WD40; WD40 repeat [structural motif]

cl25539
Location:968 → 1254

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...