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chfr checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase [ Danio rerio (zebrafish) ]

Gene ID: 564271, updated on 18-Sep-2024

Summary

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Official Symbol
chfrprovided by ZNC
Official Full Name
checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3522
See related
Ensembl:ENSDARG00000075347 AllianceGenome:ZFIN:ZDB-GENE-030131-3522
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc43f10; wu:fc43f10; si:dkey-69h6.7
Summary
Predicted to enable nucleotide binding activity and ubiquitin-protein transferase activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within cell division. Predicted to be located in PML body. Predicted to be active in nucleus. Is expressed in central nervous system and presumptive diencephalon. Orthologous to human CHFR (checkpoint with forkhead and ring finger domains). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See chfr in Genome Data Viewer
Location:
chromosome: 5
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (17780475..17813299)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (17276411..17309303)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene fibrosin-like 1 Neighboring gene uncharacterized LOC137495572 Neighboring gene uncharacterized LOC137495573 Neighboring gene si:dkey-112e17.1 Neighboring gene uncharacterized LOC137495574 Neighboring gene zinc finger DHHC-type palmitoyltransferase 8b Neighboring gene uncharacterized LOC110439809

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic G2/M transition checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic G2/M transition checkpoint ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in PML body ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase CHFR
Names
Checkpoint with forkhead and RING finger domains protein
RING-type E3 ubiquitin transferase CHFR
NP_001093485.1
XP_017211627.1
XP_017211628.1
XP_021331941.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100015.1 → NP_001093485.1  E3 ubiquitin-protein ligase CHFR

    See identical proteins and their annotated locations for NP_001093485.1

    Status: PROVISIONAL

    Source sequence(s)
    CT573109
    UniProtKB/Swiss-Prot
    A5WW08, A8E4S5
    Related
    ENSDARP00000099431.3, ENSDART00000110783.5
    Conserved Domains (2) summary
    cd00060
    Location:10 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd00162
    Location:276 → 319
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    17780475..17813299
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017356138.3 → XP_017211627.1  E3 ubiquitin-protein ligase CHFR isoform X1

    UniProtKB/Swiss-Prot
    A5WW08, A8E4S5
    Conserved Domains (2) summary
    cd00060
    Location:10 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd00162
    Location:276 → 319
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

  2. XM_021476266.2 → XP_021331941.1  E3 ubiquitin-protein ligase CHFR isoform X2

    UniProtKB/TrEMBL
    A0A8M9Q8W8
    Conserved Domains (2) summary
    cd00060
    Location:10 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd16503
    Location:273 → 316
    RING-HC_CHFR; RING finger, HC subclass, found in checkpoint with forkhead and RING finger domains protein (CHFR)

  3. XM_017356139.3 → XP_017211628.1  E3 ubiquitin-protein ligase CHFR isoform X2

    UniProtKB/TrEMBL
    A0A8M9Q8W8
    Related
    ENSDARP00000098332.2, ENSDART00000115227.2
    Conserved Domains (2) summary
    cd00060
    Location:10 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd16503
    Location:273 → 316
    RING-HC_CHFR; RING finger, HC subclass, found in checkpoint with forkhead and RING finger domains protein (CHFR)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A5WW08.1 GenPept UniProtKB/Swiss-Prot:A5WW08

Gene LinkOut

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