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usp10 ubiquitin specific peptidase 10 [ Danio rerio (zebrafish) ]

Gene ID: 564632, updated on 18-Sep-2024

Summary

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Official Symbol
usp10provided by ZNC
Official Full Name
ubiquitin specific peptidase 10provided by ZNC
Primary source
ZFIN:ZDB-GENE-030219-132
See related
Ensembl:ENSDARG00000103422 AllianceGenome:ZFIN:ZDB-GENE-030219-132
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
id:ibd1190; wu:fc19h08; wu:fc76g05; wu:fi11g01
Summary
Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in DNA damage response, signal transduction by p53 class mediator; protein deubiquitination; and regulation of autophagy. Predicted to act upstream of or within DNA repair; autophagy; and ubiquitin-dependent protein catabolic process. Predicted to be active in cytosol and nucleus. Is expressed in immature eye and optic tectum. Orthologous to human USP10 (ubiquitin specific peptidase 10). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See usp10 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (69146684..69184445, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (68923913..68961751, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene hepatocyte nuclear factor 4-gamma-like Neighboring gene hepatic nuclear factor 4, beta Neighboring gene cysteine-rich secretory protein LCCL domain containing 2 Neighboring gene MARVEL domain containing 3 Neighboring gene PH domain and leucine rich repeat protein phosphatase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. Tse WK, et al. BMC Genomics, 2009 Dec 30. PMID 20040115, Free PMC Article
  2. A gene expression screen in zebrafish embryogenesis. Kudoh T, et al. Genome Res, 2001 Dec. PMID 11731487
  3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response, signal transduction by p53 class mediator IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein stability IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 10
Names
ubiquitin specific protease 10
XP_005169108.1
XP_005169109.1
XP_068078884.1
XP_685621.5

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    69146684..69184445 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068222783.1 → XP_068078884.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X4

  2. XM_005169052.5 → XP_005169109.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X3

    UniProtKB/TrEMBL
    A0A8M2BGF3
    Related
    ENSDARP00000145430.1, ENSDART00000191359.1
    Conserved Domains (2) summary
    cd02257
    Location:567 → 840
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:460 → 839
    UCH; Ubiquitin carboxyl-terminal hydrolase

  3. XM_005169051.5 → XP_005169108.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X2

    UniProtKB/TrEMBL
    A0A8M2BGE9
    Conserved Domains (2) summary
    cd02257
    Location:587 → 859
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:480 → 858
    UCH; Ubiquitin carboxyl-terminal hydrolase

  4. XM_680529.10 → XP_685621.5  ubiquitin carboxyl-terminal hydrolase 10 isoform X1

    UniProtKB/TrEMBL
    A0A0R4IVE2, A0A8N7UVN4
    Related
    ENSDARP00000139500.1, ENSDART00000161319.2
    Conserved Domains (2) summary
    cd02257
    Location:587 → 860
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:480 → 859
    UCH; Ubiquitin carboxyl-terminal hydrolase
Nucleotide Protein Strain
Heading Accession and Version

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