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tdrd6a tudor domain containing 6a [ Danio rerio (zebrafish) ]

Gene ID: 565665, updated on 14-Nov-2024

Summary

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Official Symbol
tdrd6aprovided by ZNC
Official Full Name
tudor domain containing 6aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041001-210
See related
Ensembl:ENSDARG00000070052 AllianceGenome:ZFIN:ZDB-GENE-041001-210
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
tdrd6; si:dkey-30j22.9
Summary
Involved in P granule assembly; regulation of oogenesis; and spermatogenesis. Located in P granule and chromatoid body. Is active in germ plasm and mitochondrial cloud. Orthologous to human TDRD6 (tudor domain containing 6). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See tdrd6a in Genome Data Viewer
Location:
chromosome: 20
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (35438392..35462213)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (35535420..35559334)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene visinin-like 1a Neighboring gene splicing factor 3b, subunit 6 Neighboring gene phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) Neighboring gene meprin A, alpha (PABA peptide hydrolase), tandem duplicate 1 Neighboring gene meprin A, alpha (PABA peptide hydrolase), tandem duplicate 2 Neighboring gene adhesion G protein-coupled receptor F3b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Tdrd6a Regulates the Aggregation of Buc into Functional Subcellular Compartments that Drive Germ Cell Specification. Roovers EF, et al. Dev Cell, 2018 Aug 6. PMID 30086300, Free PMC Article
  2. Comparative studies on duplicated tdrd7 paralogs in teleosts: Molecular evolution caused neo-functionalization. Wang B, et al. Comp Biochem Physiol Part D Genomics Proteomics, 2019 Jun. PMID 31059868
  3. Stress decreases spermatozoa quality and induces molecular alterations in zebrafish progeny. Valcarce DG, et al. BMC Biol, 2023 Apr 3. PMID 37013516, Free PMC Article
  4. Exploring uncoupling proteins and antioxidant mechanisms under acute cold exposure in brains of fish. Tseng YC, et al. PLoS One, 2011 Mar 25. PMID 21464954, Free PMC Article
  5. Abrogation of Stem Loop Binding Protein (Slbp) function leads to a failure of cells to transition from proliferation to differentiation, retinal coloboma and midline axon guidance deficits. Turner KJ, et al. PLoS One, 2019. PMID 30695021, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in P granule assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in P granule organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in germ cell development IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within oogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in organelle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in piRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of oogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in P granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in P granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromatoid body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in germ plasm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in mitochondrial cloud IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
tudor domain-containing 6
Names
tudor domain containing 6
tudor domain-containing protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001423790.1 → NP_001410719.1  tudor domain-containing 6

    Status: VALIDATED

    Source sequence(s)
    BX510920, CK870521, EB910631, EB911109, EB916560, EE701388
    UniProtKB/Swiss-Prot
    F1R237, F1RE34
    Related
    ENSDARP00000093281.2, ENSDART00000102504.4

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    35438392..35462213
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_011007691.1 RNA Sequence

  2. XR_011007692.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F1R237.2 GenPept UniProtKB/Swiss-Prot:F1R237

Gene LinkOut

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