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emc10 ER membrane protein complex subunit 10 [ Danio rerio (zebrafish) ]

Gene ID: 565829, updated on 12-Sep-2024

Summary

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Official Symbol
emc10provided by ZNC
Official Full Name
ER membrane protein complex subunit 10provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9045
See related
Ensembl:ENSDARG00000054793 AllianceGenome:ZFIN:ZDB-GENE-030131-9045
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fa97d10; wu:fa97d10; zgc:171980
Summary
Predicted to contribute to membrane insertase activity. Predicted to be involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Predicted to be integral component of endoplasmic reticulum membrane. Predicted to be part of EMC complex. Orthologous to human EMC10 (ER membrane protein complex subunit 10). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See emc10 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (30241237..30248290, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (30110395..30117448, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene zgc:195001 Neighboring gene uncharacterized LOC137490618 Neighboring gene myosin binding protein Ca Neighboring gene leucine rich repeat containing 4Ba

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Raman R, et al. Sci Rep, 2021 Jul 27. PMID 34315984, Free PMC Article
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC171980

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
contributes_to membrane insertase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tail-anchored membrane protein insertion into ER membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of EMC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of EMC complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ER membrane protein complex subunit 10
Names
UPF0510 protein INM02

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102389.2 → NP_001095859.2  ER membrane protein complex subunit 10 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC150420, EH531631, EH586841
    UniProtKB/Swiss-Prot
    A7E2M3
    UniProtKB/TrEMBL
    F1QB44
    Related
    ENSDARP00000071497.3, ENSDART00000077029.4

  2. NM_001163918.1 → NP_001157390.1  ER membrane protein complex subunit 10 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 3' coding region compared to variant 1. The resulting protein (isoform 2) has a shorter, distinct C-terminus compared to isoform 1.
    Source sequence(s)
    EH461036, EH531631, EH586841
    UniProtKB/Swiss-Prot
    A7E2M3
    UniProtKB/TrEMBL
    A0A8M1NV41, E9QGR8
    Related
    ENSDARP00000122489.1, ENSDART00000133516.3

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    30241237..30248290 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A7E2M3.1 GenPept UniProtKB/Swiss-Prot:A7E2M3

Gene LinkOut

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