plekhh1 pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: plekhh1provided by ZNC
Official Full Name: pleckstrin homology domain containing, family H (with MyTH4 domain) member 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-061219-1
See related: Ensembl:ENSDARG00000053835 AllianceGenome:ZFIN:ZDB-GENE-061219-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: max1; im:6897489; im:7143671
Summary: Acts upstream of or within branching involved in blood vessel morphogenesis. Predicted to be located in cytoskeleton. Is expressed in several structures, including digestive system; hindbrain neural plate; nervous system; pectoral fin bud; and trunk. Orthologous to human PLEKHH1 (pleckstrin homology, MyTH4 and FERM domain containing H1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (37932738..38021592)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (37985153..38074007)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we uncovered regulators and targets of homeobox gene MSX1 in leukemia/lymphoma cells, supporting the view of a recurrent genetic network that is reactivated in malignant transformation.
Title: Oncogenic deregulation of NKL homeobox gene MSX1 in mantle cell lymphoma.
max-1, acting upstream of the ephrin pathway, is critically required in vascular patterning
Title: Vertebrate MAX-1 is required for vascular patterning in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

G41714 (e-PCR)
- UniSTS:49450

fb38h11.x1 (e-PCR)
- UniSTS:190550

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
NOT acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within branching involved in blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pleckstrin homology domain-containing family H member 1

Names: PH domain-containing family H member 1; max-1; pleckstrin homology domain containing, family H, member 1; protein max-1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077519.2 → NP_001070987.1 pleckstrin homology domain-containing family H member 1

See identical proteins and their annotated locations for NP_001070987.1

Status: PROVISIONAL

Source sequence(s)

DQ501275

UniProtKB/Swiss-Prot

Q00IB7

Related

ENSDARP00000070420.4, ENSDART00000075941.5

Conserved Domains (9) summary

smart00139
Location:896 → 1050

MyTH4; Domain in Myosin and Kinesin Tails

smart00233
Location:755 → 854

PH; Pleckstrin homology domain

smart00295
Location:1063 → 1293

B41; Band 4.1 homologues

cd13206
Location:1289 → 1390

FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H

cd13282
Location:646 → 741

PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1

pfam00169
Location:644 → 737

PH; PH domain

pfam00373
Location:1168 → 1293

FERM_M; FERM central domain

cd16269
Location:145 → 156

GBP_C; coiled coil [structural motif]

cl20817
Location:47 → 156

GBP_C; Guanylate-binding protein, C-terminal domain