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slc4a2a solute carrier family 4 member 2a [ Danio rerio (zebrafish) ]

Gene ID: 566075, updated on 17-Sep-2024

Summary

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Official Symbol
slc4a2aprovided by ZNC
Official Full Name
solute carrier family 4 member 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-051101-2
See related
Ensembl:ENSDARG00000028173 AllianceGenome:ZFIN:ZDB-GENE-051101-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
slc4a2
Summary
Enables anion:anion antiporter activity. Acts upstream of or within anion transport. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including cardiovascular system; immature eye; midbrain neural rod; optic tectum; and pronephric duct. Orthologous to human SLC4A2 (solute carrier family 4 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See slc4a2a in Genome Data Viewer
Location:
chromosome: 2
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (32391897..32457941, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (32408671..32474705, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 1a Neighboring gene upstream binding transcription factor, like Neighboring gene tetratricopeptide repeat domain 19 Neighboring gene Fas apoptotic inhibitory molecule 2a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish slc4a2/ae2 anion exchanger: cDNA cloning, mapping, functional characterization, and localization. Shmukler BE, et al. Am J Physiol Renal Physiol, 2005 Oct. PMID 15914778
  2. Zebrafish ae2.2 encodes a second slc4a2 anion exchanger. Shmukler BE, et al. Am J Physiol Regul Integr Comp Physiol, 2008 Mar. PMID 18046018
  3. Molecular cloning and functional characterization of zebrafish Slc4a3/Ae3 anion exchanger. Shmukler BE, et al. Pflugers Arch, 2014 Aug. PMID 24668450, Free PMC Article
  4. osr1 is required for podocyte development downstream of wt1a. Tomar R, et al. J Am Soc Nephrol, 2014 Nov. PMID 24722440, Free PMC Article
  5. Anion exchanger 1b, but not sodium-bicarbonate cotransporter 1b, plays a role in transport functions of zebrafish H+-ATPase-rich cells. Lee YC, et al. Am J Physiol Cell Physiol, 2011 Feb. PMID 21123736

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables chloride:bicarbonate antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoatomic anion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables solute:inorganic anion antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in bicarbonate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic anion transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within monoatomic anion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
anion exchange protein 2a
Names
ae2
ae2.1
anion exchanger 2
solute carrier family 4 (anion exchanger), member 2a
solute carrier family 4, anion exchanger, member 2
solute carrier family 4, anion exchanger, member 2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037237.1 → NP_001032314.1  anion exchange protein 2a

    See identical proteins and their annotated locations for NP_001032314.1

    Status: PROVISIONAL

    Source sequence(s)
    AY876015
    UniProtKB/TrEMBL
    Q3KVL6
    Related
    ENSDARP00000041318.4, ENSDART00000041319.6
    Conserved Domains (3) summary
    TIGR00834
    Location:326 → 1227
    ae; anion exchange protein
    pfam00955
    Location:676 → 1155
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:361 → 625
    Band_3_cyto; Band 3 cytoplasmic domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    32391897..32457941 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021480959.2 → XP_021336634.1  anion exchange protein 2a isoform X1

    UniProtKB/TrEMBL
    A0A8M9PZ09
    Conserved Domains (1) summary
    TIGR00834
    Location:345 → 1246
    ae; anion exchange protein

  2. XM_021480957.2 → XP_021336632.1  anion exchange protein 2a isoform X1

    UniProtKB/TrEMBL
    A0A8M9PZ09
    Conserved Domains (1) summary
    TIGR00834
    Location:345 → 1246
    ae; anion exchange protein

  3. XM_068224652.1 → XP_068080753.1  anion exchange protein 2a isoform X2

  4. XM_068224655.1 → XP_068080756.1  anion exchange protein 2a isoform X3

  5. XM_005163511.5 → XP_005163568.1  anion exchange protein 2a isoform X1

    See identical proteins and their annotated locations for XP_005163568.1

    UniProtKB/TrEMBL
    A0A8M9PZ09
    Conserved Domains (1) summary
    TIGR00834
    Location:345 → 1246
    ae; anion exchange protein
Nucleotide Protein Strain
Heading Accession and Version

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