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tinf2 TERF1 (TRF1)-interacting nuclear factor 2 [ Danio rerio (zebrafish) ]

Gene ID: 566362, updated on 2-Nov-2024

Summary

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Official Symbol
tinf2provided by ZNC
Official Full Name
TERF1 (TRF1)-interacting nuclear factor 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-6168
See related
Ensembl:ENSDARG00000054473 AllianceGenome:ZFIN:ZDB-GENE-030131-6168
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
TIN2; wu:fi37c10; zgc:158289
Summary
Predicted to enable telomeric DNA binding activity. Predicted to be involved in regulation of telomere maintenance via telomere lengthening and telomere capping. Predicted to be part of shelterin complex. Is expressed in several structures, including blastomere; digestive system; gill; heart; and ovary. Human ortholog(s) of this gene implicated in Revesz syndrome and autosomal dominant dyskeratosis congenita 3. Orthologous to human TINF2 (TERF1 interacting nuclear factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See tinf2 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (24019493..24040061)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (23748336..23768900)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene si:dkey-183c6.9 Neighboring gene coiled-coil domain containing 166 Neighboring gene homeobox and leucine zipper encoding b Neighboring gene cell death inducing DFFA like effector b Neighboring gene dehydrogenase/reductase (SDR family) member 4 Neighboring gene embryonal Fyn-associated substrate

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish as a model system to study the physiological function of telomeric protein TPP1. Xie Y, et al. PLoS One, 2011 Feb 2. PMID 21311760, Free PMC Article
  2. The knockdown efficiency of telomere associated genes with specific methodology in a zebrafish cell line. Hu X, et al. Biochimie, 2021 Nov. PMID 34214617
  3. Knockout of Shelterin subunit genes in zebrafish results in distinct outcomes. Ma J, et al. Biochem Biophys Res Commun, 2022 Aug 20. PMID 35667242
  4. The differential spatiotemporal expression pattern of shelterin genes throughout lifespan. Wagner KD, et al. Aging (Albany NY), 2017 Apr. PMID 28437249, Free PMC Article
  5. The non-telomeric evolutionary trajectory of TRF2 in zebrafish reveals its specific roles in neurodevelopment and aging. Ying Y, et al. Nucleic Acids Res, 2022 Feb 28. PMID 35150283, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC158289

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of telomere maintenance via telomere lengthening IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in telomere capping IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within telomere capping IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of shelterin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of shelterin complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
TERF1-interacting nuclear factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001386364.1 → NP_001373293.1  TERF1-interacting nuclear factor 2

    Status: VALIDATED

    Source sequence(s)
    CR388231
    UniProtKB/TrEMBL
    A0A8M2BK53, F1R9M2
    Related
    ENSDARP00000113476.1, ENSDART00000141165.2
    Conserved Domains (1) summary
    pfam14973
    Location:38 → 182
    TINF2_N; TERF1-interacting nuclear factor 2 N-terminus

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    24019493..24040061
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009303073.3 → XP_009301348.1  TERF1-interacting nuclear factor 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M3AU25
    Conserved Domains (1) summary
    cd11657
    Location:8 → 196
    TIN2_N; N-terminal domain of TRF-interacting nuclear factor 2; shelterin complex protein of telomeres

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001080027.1: Suppressed sequence

    Description
    NM_001080027.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from zebrafish: zgc:113263 (GeneID:503753).
Nucleotide Protein Strain
Heading Accession and Version

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