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dnai7 dynein axonemal intermediate chain 7 [ Danio rerio (zebrafish) ]

Gene ID: 566485, updated on 2-Nov-2024

Summary

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Official Symbol
dnai7provided by ZNC
Official Full Name
dynein axonemal intermediate chain 7provided by ZNC
Primary source
ZFIN:ZDB-GENE-041210-153
See related
Ensembl:ENSDARG00000016815 AllianceGenome:ZFIN:ZDB-GENE-041210-153
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
casc1; cfap94; si:dkey-172o10.5
Summary
Predicted to enable beta-tubulin binding activity and microtubule binding activity. Predicted to be located in cell projection and cytoplasm. Predicted to be active in axoneme. Is expressed in forerunner cell group; neural plate; neural rod; neural tube; and spinal cord. Orthologous to human DNAI7 (dynein axonemal intermediate chain 7). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See dnai7 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (17245005..17252372)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (17256004..17263396)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene SRY-box transcription factor 5 Neighboring gene uncharacterized LOC137491396 Neighboring gene uncharacterized LOC137491539 Neighboring gene lymphoid-restricted membrane protein Neighboring gene branched chain amino-acid transaminase 1, cytosolic Neighboring gene insulin-like growth factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Regulation of spermatogonial development by Fsh: The complementary roles of locally produced Igf and Wnt signaling molecules in adult zebrafish testis. Safian D, et al. Gen Comp Endocrinol, 2019 Dec 1. PMID 31415728
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables beta-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dynein axonemal intermediate chain 7
Names
cancer susceptibility 1
cancer susceptibility candidate 1 like
cancer susceptibility candidate gene 1 protein homolog
cancer susceptibility candidate protein 1 homolog
cilia and flagella associated protein 94
dynein intermediate chain CFAP94, axonemal
protein CASC1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099454.1 → NP_001092924.1  dynein axonemal intermediate chain 7

    Status: PROVISIONAL

    Source sequence(s)
    BX547928
    UniProtKB/Swiss-Prot
    A6H8T2, Q5RHB4
    UniProtKB/TrEMBL
    A0A8M1NDW9, T1ECS4
    Related
    ENSDARP00000012780.5, ENSDART00000027645.6
    Conserved Domains (2) summary
    pfam12366
    Location:457 → 615
    Casc1; Cancer susceptibility candidate 1
    pfam15927
    Location:64 → 227
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    17245005..17252372
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005164764.5 → XP_005164821.1  dynein axonemal intermediate chain 7 isoform X1

    UniProtKB/Swiss-Prot
    A6H8T2, Q5RHB4
    UniProtKB/TrEMBL
    A0A8M2BC09
    Related
    ENSDARP00000104413.3, ENSDART00000110908.4
    Conserved Domains (2) summary
    pfam12366
    Location:244 → 471
    Casc1; Cancer susceptibility candidate 1
    pfam15927
    Location:64 → 227
    Casc1_N; Cancer susceptibility candidate 1 N-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6H8T2.2 GenPept UniProtKB/Swiss-Prot:A6H8T2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.