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ddx3xa DEAD-box helicase 3 X-linked a [ Danio rerio (zebrafish) ]

Gene ID: 566947, updated on 2-Nov-2024

Summary

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Official Symbol
ddx3xaprovided by ZNC
Official Full Name
DEAD-box helicase 3 X-linked aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1565
See related
Ensembl:ENSDARG00000020573 AllianceGenome:ZFIN:ZDB-GENE-030131-1565
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ddx3; ddx3a; fb74g09; wu:fb74g09; zgc:158804
Summary
Predicted to enable RNA helicase activity and mRNA binding activity. Predicted to be involved in cell differentiation; gamete generation; and negative regulation of gene expression. Predicted to be active in P granule and nucleus. Human ortholog(s) of this gene implicated in colorectal cancer and syndromic X-linked intellectual disability. Orthologous to human DDX3X (DEAD-box helicase 3 X-linked). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See ddx3xa in Genome Data Viewer
Location:
chromosome: 9
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (33334495..33354738)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (33523711..33544134)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 9 Neighboring gene ribosomal protein L8 Neighboring gene calcium/calmodulin-dependent serine protein kinase a Neighboring gene nyctalopin Neighboring gene G protein-coupled receptor 34b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A hypomorphic inherited pathogenic variant in DDX3X causes male intellectual disability with additional neurodevelopmental and neurodegenerative features. Kellaris G, et al. Hum Genomics, 2018 Mar 1. PMID 29490693, Free PMC Article
  2. DDX3 Participates in Translational Control of Inflammation Induced by Infections and Injuries. Ku YC, et al. Mol Cell Biol, 2019 Jan 1. PMID 30373933, Free PMC Article
  3. Viral infection-induced changes in the expression profile of non-RLR DExD/H-box RNA helicases (DDX1, DDX3, DHX9, DDX21 and DHX36) in zebrafish and common carp. Mojzesz M, et al. Fish Shellfish Immunol, 2020 Sep. PMID 32526283
  4. Transcriptional regulation in liver and testis associated with developmental and reproductive effects in male zebrafish exposed to natural mixtures of persistent organic pollutants (POP). Nourizadeh-Lillabadi R, et al. J Toxicol Environ Health A, 2009. PMID 19184727
  5. Type I interferon-dependent response of zebrafish larvae during tilapia lake virus (TiLV) infection. Widziolek M, et al. Dev Comp Immunol, 2021 Mar. PMID 33242567

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gamete generation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of neutrophil chemotaxis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of neutrophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in P granule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DEAD-box helicase 3 X-linked a
Names
DEAD (Asp-Glu-Ala-Asp) box helicase 3
DEAD (Asp-Glu-Ala-Asp) box helicase 3a
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3
NP_001119895.1
XP_005167775.1
XP_005167777.1
XP_009303026.1
XP_017213194.1
XP_017213195.1
XP_021334401.1
XP_021334402.1
XP_021334403.1
XP_021334404.1
XP_021334405.1
XP_021334406.1
XP_021334408.1
XP_021334409.1
XP_021334410.1
XP_021334411.1
XP_068079542.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001126423.1 → NP_001119895.1  DEAD-box helicase 3 X-linked a

    Status: PROVISIONAL

    Source sequence(s)
    BX545856
    UniProtKB/TrEMBL
    A0A8M1NJ99, B0S6P6
    Related
    ENSDARP00000002260.7, ENSDART00000006867.9
    Conserved Domains (3) summary
    cd00268
    Location:225 → 452
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    PTZ00110
    Location:105 → 656
    PTZ00110; helicase; Provisional
    pfam00271
    Location:473 → 584
    Helicase_C; Helicase conserved C-terminal domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    33334495..33354738
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021478726.2 → XP_021334401.1  DEAD-box helicase 3 X-linked a isoform X1

    UniProtKB/TrEMBL
    A0A8M9QFI7
    Conserved Domains (1) summary
    COG0513
    Location:331 → 779
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

  2. XM_021478728.2 → XP_021334403.1  DEAD-box helicase 3 X-linked a isoform X3

    UniProtKB/TrEMBL
    A0A8M9Q4N5
    Conserved Domains (1) summary
    COG0513
    Location:331 → 778
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

  3. XM_021478731.2 → XP_021334406.1  DEAD-box helicase 3 X-linked a isoform X6

    UniProtKB/TrEMBL
    A0A8M9QFJ0
    Conserved Domains (1) summary
    COG0513
    Location:303 → 751
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

  4. XM_021478733.2 → XP_021334408.1  DEAD-box helicase 3 X-linked a isoform X7

    UniProtKB/TrEMBL
    A0A8M9Q4N8
    Conserved Domains (1) summary
    COG0513
    Location:302 → 750
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

  5. XM_021478735.2 → XP_021334410.1  DEAD-box helicase 3 X-linked a isoform X9

    UniProtKB/TrEMBL
    A0A8M9QJS4
    Conserved Domains (1) summary
    COG0513
    Location:274 → 722
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

  6. XM_005167718.5 → XP_005167775.1  DEAD-box helicase 3 X-linked a isoform X10

    UniProtKB/TrEMBL
    A0A8M2BF62
    Conserved Domains (3) summary
    cd00268
    Location:245 → 472
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    PTZ00110
    Location:125 → 676
    PTZ00110; helicase; Provisional
    pfam00271
    Location:493 → 604
    Helicase_C; Helicase conserved C-terminal domain

  7. XM_017357706.3 → XP_017213195.1  DEAD-box helicase 3 X-linked a isoform X12

    UniProtKB/TrEMBL
    A0A8M6Z099

  8. XM_021478727.2 → XP_021334402.1  DEAD-box helicase 3 X-linked a isoform X2

    UniProtKB/TrEMBL
    A0A8M9PS93
    Conserved Domains (1) summary
    COG0513
    Location:330 → 778
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

  9. XM_017357705.3 → XP_017213194.1  DEAD-box helicase 3 X-linked a isoform X11

    UniProtKB/TrEMBL
    A0A8M6Z8G4

  10. XM_021478730.2 → XP_021334405.1  DEAD-box helicase 3 X-linked a isoform X5

    UniProtKB/TrEMBL
    A0A8M9QJR9
    Conserved Domains (1) summary
    COG0513
    Location:311 → 759
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

  11. XM_021478734.2 → XP_021334409.1  DEAD-box helicase 3 X-linked a isoform X8

    UniProtKB/TrEMBL
    A0A8M9QAW2
    Conserved Domains (1) summary
    COG0513
    Location:282 → 730
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

  12. XM_009304751.4 → XP_009303026.1  DEAD-box helicase 3 X-linked a isoform X14

    UniProtKB/TrEMBL
    A0A8M3B2Q5
    Conserved Domains (3) summary
    cd00268
    Location:225 → 451
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    PTZ00110
    Location:105 → 655
    PTZ00110; helicase; Provisional
    pfam00271
    Location:472 → 583
    Helicase_C; Helicase conserved C-terminal domain

  13. XM_021478729.2 → XP_021334404.1  DEAD-box helicase 3 X-linked a isoform X4

    UniProtKB/TrEMBL
    A0A8M9QAW0
    Conserved Domains (1) summary
    COG0513
    Location:315 → 763
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

  14. XM_021478736.2 → XP_021334411.1  DEAD-box helicase 3 X-linked a isoform X13

    UniProtKB/TrEMBL
    A0A8M9QFJ5
    Conserved Domains (1) summary
    COG0513
    Location:203 → 651
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

  15. XM_005167720.5 → XP_005167777.1  DEAD-box helicase 3 X-linked a isoform X15

    UniProtKB/TrEMBL
    A0A8M2BF54
    Conserved Domains (3) summary
    cd00268
    Location:209 → 436
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    PTZ00110
    Location:89 → 640
    PTZ00110; helicase; Provisional
    pfam00271
    Location:457 → 568
    Helicase_C; Helicase conserved C-terminal domain

  16. XM_068223441.1 → XP_068079542.1  DEAD-box helicase 3 X-linked a isoform X16

Nucleotide Protein Strain
Heading Accession and Version

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