U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

itpr1a inositol 1,4,5-trisphosphate receptor, type 1a [ Danio rerio (zebrafish) ]

Gene ID: 567611, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
itpr1aprovided by ZNC
Official Full Name
inositol 1,4,5-trisphosphate receptor, type 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070604-3
See related
Ensembl:ENSDARG00000014655 AllianceGenome:ZFIN:ZDB-GENE-070604-3
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable inositol 1,4,5 trisphosphate binding activity and inositol 1,4,5-trisphosphate-gated calcium channel activity. Predicted to be involved in release of sequestered calcium ion into cytosol. Predicted to act upstream of or within calcium ion transmembrane transport. Predicted to be located in endoplasmic reticulum membrane and transport vesicle membrane. Human ortholog(s) of this gene implicated in Gillespie syndrome; spinocerebellar ataxia type 15; and spinocerebellar ataxia type 29. Orthologous to human ITPR1 (inositol 1,4,5-trisphosphate receptor type 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See itpr1a in Genome Data Viewer
Location:
chromosome: 6
Exon count:
61
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (39923052..39994101)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (39925511..39993961)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene endonuclease, polyU-specific Neighboring gene sulfatase modifying factor 1 Neighboring gene 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4b Neighboring gene uncharacterized LOC101883560 Neighboring gene uncharacterized LOC101883484

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Abnormal cerebellar development and ataxia in CARP VIII morphant zebrafish. Aspatwar A, et al. Hum Mol Genet, 2013 Feb 1. PMID 23087022
  2. Molecular and functional characterization of inositol trisphosphate receptors during early zebrafish development. Ashworth R, et al. J Biol Chem, 2007 May 11. PMID 17331947
  3. Identification of Ca(2+) signaling components in neural stem/progenitor cells during differentiation into neurons and glia in intact and dissociated zebrafish neurospheres. Tse MK, et al. Sci China Life Sci, 2018 Nov. PMID 29931586
  4. Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. Sato Y, et al. BMC Evol Biol, 2009 Jun 5. PMID 19500364, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol 1,4,5 trisphosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables inositol 1,4,5-trisphosphate-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in release of sequestered calcium ion into cytosol IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
Names
ITPR1b1
ITPR1b3
inositol 1,4,5-triphosphate receptor, type 1a

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    39923052..39994101
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005166095.5 → XP_005166152.1  inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BDG0
    Conserved Domains (7) summary
    smart00472
    Location:231 → 287
    MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
    pfam00520
    Location:2329 → 2562
    Ion_trans; Ion transport protein
    pfam01365
    Location:476 → 665
    RYDR_ITPR; RIH domain
    pfam02815
    Location:233 → 433
    MIR; MIR domain
    pfam08454
    Location:1944 → 2049
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:6 → 225
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    pfam14329
    Location:2374 → 2442
    DUF4386; Domain of unknown function (DUF4386)

  2. XM_009302588.4 → XP_009300863.1  inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform X6

    UniProtKB/TrEMBL
    A0A8M3B0M5
    Conserved Domains (7) summary
    smart00472
    Location:231 → 287
    MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
    pfam00520
    Location:2301 → 2534
    Ion_trans; Ion transport protein
    pfam01365
    Location:476 → 665
    RYDR_ITPR; RIH domain
    pfam02815
    Location:233 → 433
    MIR; MIR domain
    pfam08454
    Location:1916 → 2021
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:6 → 225
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    pfam14329
    Location:2346 → 2414
    DUF4386; Domain of unknown function (DUF4386)

  3. XM_009302585.4 → XP_009300860.1  inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform X2

    UniProtKB/TrEMBL
    A0A8M3ATJ5
    Conserved Domains (7) summary
    smart00472
    Location:231 → 287
    MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
    pfam00520
    Location:2328 → 2561
    Ion_trans; Ion transport protein
    pfam01365
    Location:476 → 665
    RYDR_ITPR; RIH domain
    pfam02815
    Location:233 → 433
    MIR; MIR domain
    pfam08454
    Location:1943 → 2048
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:6 → 225
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    pfam14329
    Location:2373 → 2441
    DUF4386; Domain of unknown function (DUF4386)

  4. XM_017356665.3 → XP_017212154.1  inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform X7

    UniProtKB/TrEMBL
    A0A8M6Z1A3, F8W4B1
    Related
    ENSDARP00000123931.1, ENSDART00000149019.3

  5. XM_068222023.1 → XP_068078124.1  inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform X3

  6. XM_009302587.4 → XP_009300862.1  inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform X4

    UniProtKB/TrEMBL
    A0A8M3B3K9
    Conserved Domains (7) summary
    smart00472
    Location:231 → 287
    MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
    pfam00520
    Location:2314 → 2547
    Ion_trans; Ion transport protein
    pfam01365
    Location:461 → 650
    RYDR_ITPR; RIH domain
    pfam02815
    Location:233 → 418
    MIR; MIR domain
    pfam08454
    Location:1929 → 2034
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:6 → 225
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    pfam14329
    Location:2359 → 2427
    DUF4386; Domain of unknown function (DUF4386)

  7. XM_017356664.3 → XP_017212153.1  inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform X5

    UniProtKB/TrEMBL
    A0A8M6YZS1

  8. XM_017356666.3 → XP_017212155.1  inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform X8

    UniProtKB/TrEMBL
    A0A8M6Z7H7
    Related
    ENSDARP00000065091.7, ENSDART00000065092.7

Reference GRCz11 ALT_DRER_TU_3

Genomic

  1. NW_018395382.1 Reference GRCz11 ALT_DRER_TU_3

    Range
    258852..327556
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021474612.2 → XP_021330287.1  inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform X9

    UniProtKB/TrEMBL
    A0A8M9PGB9
    Conserved Domains (5) summary
    pfam00520
    Location:2340 → 2573
    Ion_trans; Ion transport protein
    pfam01365
    Location:485 → 681
    RYDR_ITPR; RIH domain
    pfam02815
    Location:244 → 444
    MIR; MIR domain
    pfam08454
    Location:1955 → 2060
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:17 → 236
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

  2. XM_021474617.2 → XP_021330292.1  inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform X13

    UniProtKB/TrEMBL
    A0A8M9PGC5
    Conserved Domains (5) summary
    pfam00520
    Location:2312 → 2545
    Ion_trans; Ion transport protein
    pfam01365
    Location:485 → 681
    RYDR_ITPR; RIH domain
    pfam02815
    Location:244 → 444
    MIR; MIR domain
    pfam08454
    Location:1927 → 2032
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:17 → 236
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

  3. XM_021474613.2 → XP_021330288.1  inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform X10

    UniProtKB/TrEMBL
    A0A8M9PTD6
    Conserved Domains (5) summary
    pfam00520
    Location:2339 → 2572
    Ion_trans; Ion transport protein
    pfam01365
    Location:485 → 681
    RYDR_ITPR; RIH domain
    pfam02815
    Location:244 → 444
    MIR; MIR domain
    pfam08454
    Location:1954 → 2059
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:17 → 236
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

  4. XM_021474618.2 → XP_021330293.1  inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform X14

    UniProtKB/TrEMBL
    A0A8M9PTE4
    Conserved Domains (5) summary
    pfam00520
    Location:2311 → 2544
    Ion_trans; Ion transport protein
    pfam01365
    Location:485 → 681
    RYDR_ITPR; RIH domain
    pfam02815
    Location:244 → 444
    MIR; MIR domain
    pfam08454
    Location:1926 → 2031
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:17 → 236
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

  5. XM_021474615.2 → XP_021330290.1  inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform X11

    UniProtKB/TrEMBL
    A0A8M9QAB8
    Conserved Domains (5) summary
    pfam00520
    Location:2325 → 2558
    Ion_trans; Ion transport protein
    pfam01365
    Location:470 → 666
    RYDR_ITPR; RIH domain
    pfam02815
    Location:244 → 429
    MIR; MIR domain
    pfam08454
    Location:1940 → 2045
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:17 → 236
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

  6. XM_021474616.2 → XP_021330291.1  inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform X12

    UniProtKB/TrEMBL
    A0A8M9Q5F0
    Conserved Domains (5) summary
    pfam00520
    Location:2324 → 2557
    Ion_trans; Ion transport protein
    pfam01365
    Location:470 → 666
    RYDR_ITPR; RIH domain
    pfam02815
    Location:244 → 429
    MIR; MIR domain
    pfam08454
    Location:1939 → 2044
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:17 → 236
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

  7. XM_021474620.2 → XP_021330295.1  inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform X15

    UniProtKB/TrEMBL
    A0A8M9QAC2
    Conserved Domains (5) summary
    pfam00520
    Location:2296 → 2529
    Ion_trans; Ion transport protein
    pfam01365
    Location:470 → 666
    RYDR_ITPR; RIH domain
    pfam02815
    Location:244 → 429
    MIR; MIR domain
    pfam08454
    Location:1911 → 2016
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:17 → 236
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

  8. XM_021474614.2 → XP_021330289.1  inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PZD0
    Conserved Domains (5) summary
    pfam00520
    Location:2329 → 2562
    Ion_trans; Ion transport protein
    pfam01365
    Location:474 → 670
    RYDR_ITPR; RIH domain
    pfam02815
    Location:233 → 433
    MIR; MIR domain
    pfam08454
    Location:1944 → 2049
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:6 → 225
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools