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sall2 spalt-like transcription factor 2 [ Danio rerio (zebrafish) ]

Gene ID: 568044, updated on 17-Sep-2024

Summary

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Official Symbol
sall2provided by ZNC
Official Full Name
spalt-like transcription factor 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030829-32
See related
Ensembl:ENSDARG00000075116 AllianceGenome:ZFIN:ZDB-GENE-030829-32
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc29e07; sb:cb763; wu:fc29e07; si:ch211-10e2.7
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in central nervous system; neural tube; and pharyngeal arch 3-7 skeleton. Human ortholog(s) of this gene implicated in coloboma. Orthologous to human SALL2 (spalt like transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See sall2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (38147516..38156824)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (38166699..38174502)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene cerebellin 12 Neighboring gene tripartite motif containing 110 Neighboring gene matrix metallopeptidase 14b (membrane-inserted) Neighboring gene apoptotic chromatin condensation inducer 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Characterization of γδ T Cells from Zebrafish Provides Insights into Their Important Role in Adaptive Humoral Immunity. Wan F, et al. Front Immunol, 2016. PMID 28119690, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sal-like protein 2; spalt-like transcription factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    38147516..38156824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068214383.1 → XP_068070484.1  sal-like protein 2 isoform X1

    Related
    ENSDARP00000148781.1, ENSDART00000180948.1

  2. XM_021467769.2 → XP_021323444.1  sal-like protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PFQ7
    Conserved Domains (3) summary
    sd00017
    Location:755 → 775
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:404 → 429
    zf-H2C2_2; Zinc-finger double domain
    cl26305
    Location:838 → 1149
    XPG_I; XPG I-region

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394506.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    192849..201969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068218036.1 → XP_068074137.1  sal-like protein 2 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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