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sybu syntabulin (syntaxin-interacting) [ Danio rerio (zebrafish) ]

Gene ID: 568207, updated on 2-Nov-2024

Summary

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Official Symbol
sybuprovided by ZNC
Official Full Name
syntabulin (syntaxin-interacting)provided by ZNC
Primary source
ZFIN:ZDB-GENE-060929-1202
See related
Ensembl:ENSDARG00000060112 AllianceGenome:ZFIN:ZDB-GENE-060929-1202
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
syn; fi06c06; wu:fi06c06; zgc:153017
Summary
Acts upstream of or within determination of dorsal identity and regulation of canonical Wnt signaling pathway. Predicted to be located in membrane. Predicted to be active in cytoplasmic microtubule. Is expressed in blastomere; oocyte stage I; unfertilized egg; and yolk. Orthologous to human SYBU (syntabulin). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See sybu in Genome Data Viewer
Location:
chromosome: 16
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (39147020..39167505)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (39196759..39217475)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene growth differentiation factor 6a Neighboring gene uncharacterized LOC137487949 Neighboring gene serine/threonine-protein kinase pim-2-like Neighboring gene uncharacterized LOC137488004

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. GSK-3 activity is critical for the orientation of the cortical microtubules and the dorsoventral axis determination in zebrafish embryos. Shao M, et al. PLoS One, 2012. PMID 22574208, Free PMC Article
  2. Kinesin-1 interacts with Bucky ball to form germ cells and is required to pattern the zebrafish body axis. Campbell PD, et al. Development, 2015 Sep 1. PMID 26253407, Free PMC Article
  3. Hecate/Grip2a acts to reorganize the cytoskeleton in the symmetry-breaking event of embryonic axis induction. Ge X, et al. PLoS Genet, 2014 Jun. PMID 24967891, Free PMC Article
  4. Genetic evidence for involvement of maternally derived Wnt canonical signaling in dorsal determination in zebrafish. Nojima H, et al. Mech Dev, 2004 Apr. PMID 15110047
  5. Syntabulin, a motor protein linker, controls dorsal determination. Nojima H, et al. Development, 2010 Mar. PMID 20150281

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Syntabulin, a motor protein linker, controls dorsal determination.
    Title: Syntabulin, a motor protein linker, controls dorsal determination.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC153017

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in axonal transport of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within determination of dorsal identity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synapse maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
syntabulin
Names
syntabulin, syntaxin-binding protein
tkk
tokkaebi

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077173.1 → NP_001070641.1  syntabulin

    See identical proteins and their annotated locations for NP_001070641.1

    Status: PROVISIONAL

    Source sequence(s)
    BC124210
    UniProtKB/TrEMBL
    Q08CJ9
    Related
    ENSDARP00000078816.3, ENSDART00000084381.5
    Conserved Domains (1) summary
    pfam15290
    Location:199 → 397
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    39147020..39167505
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005158223.5 → XP_005158280.1  syntabulin isoform X1

    UniProtKB/TrEMBL
    A0A8M2B4L2
    Conserved Domains (1) summary
    pfam15290
    Location:185 → 383
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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