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bcar1 BCAR1 scaffold protein, Cas family member [ Danio rerio (zebrafish) ]

Gene ID: 568309, updated on 28-Oct-2024

Summary

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Official Symbol
bcar1provided by ZNC
Official Full Name
BCAR1 scaffold protein, Cas family memberprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-2774
See related
Ensembl:ENSDARG00000056525 AllianceGenome:ZFIN:ZDB-GENE-030131-2774
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc17f11; wu:fc17f11; zgc:175192
Summary
Acts upstream of or within regulation of lymphangiogenesis and regulation of sprouting angiogenesis. Predicted to be located in anchoring junction. Predicted to be active in cytoplasm and focal adhesion. Predicted to colocalize with plasma membrane. Human ortholog(s) of this gene implicated in breast ductal carcinoma. Orthologous to human BCAR1 (BCAR1 scaffold protein, Cas family member). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
human mouse all
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Genomic context

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See bcar1 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (22503770..22688073)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (22514584..22699007)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 170A Neighboring gene craniofacial development protein 1 Neighboring gene uncharacterized LOC137488279 Neighboring gene si:dkey-11d18.2 Neighboring gene nudix hydrolase 21 Neighboring gene heat shock transcription factor 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. P130Cas/bcar1 mediates zebrafish caudal vein plexus angiogenesis. Wisniewski L, et al. Sci Rep, 2020 Sep 24. PMID 32973180, Free PMC Article
  2. Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits. O'Hare EA, et al. Mol Endocrinol, 2016 Apr. PMID 26963759, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC175192

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of lymphangiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
breast cancer anti-estrogen resistance protein 1
Names
BCAR1, Cas family scaffold protein
breast cancer anti-estrogen resistance 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135133.2 → NP_001128605.1  breast cancer anti-estrogen resistance protein 1

    See identical proteins and their annotated locations for NP_001128605.1

    Status: VALIDATED

    Source sequence(s)
    BC168512, CR933017
    UniProtKB/TrEMBL
    A0A8M1NIP6, B5DE36
    Related
    ENSDARP00000106517.2, ENSDART00000128965.3
    Conserved Domains (3) summary
    cd12001
    Location:4 → 70
    SH3_BCAR1; Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1
    pfam08824
    Location:488 → 643
    Serine_rich; Serine rich protein interaction domain
    pfam12026
    Location:705 → 913
    DUF3513; Domain of unknown function (DUF3513)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    22503770..22688073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021467686.2 → XP_021323361.1  breast cancer anti-estrogen resistance protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PM80
    Related
    ENSDARP00000144076.1, ENSDART00000176130.2
    Conserved Domains (5) summary
    cd11552
    Location:530 → 686
    Serine_rich_BCAR1; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
    cd12001
    Location:46 → 112
    SH3_BCAR1; Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1
    pfam08703
    Location:764 → 815
    PLC-beta_C; PLC-beta C terminal
    cl13463
    Location:827 → 958
    FAT-like_CAS_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module
    cl27975
    Location:123 → 254
    EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)

  2. XM_005159138.5 → XP_005159195.1  breast cancer anti-estrogen resistance protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A2R8Q9D0, A0A8M2B621
    Related
    ENSDARP00000147960.1, ENSDART00000184472.1
    Conserved Domains (3) summary
    cd12001
    Location:31 → 97
    SH3_BCAR1; Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1
    pfam08824
    Location:515 → 670
    Serine_rich; Serine rich protein interaction domain
    pfam12026
    Location:732 → 940
    DUF3513; Domain of unknown function (DUF3513)

  3. XM_005159139.5 → XP_005159196.1  breast cancer anti-estrogen resistance protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A2R8QJQ5, A0A8M2B5Q8
    Related
    ENSDARP00000152559.1, ENSDART00000192281.1
    Conserved Domains (3) summary
    pfam08824
    Location:488 → 643
    Serine_rich; Serine rich protein interaction domain
    pfam12026
    Location:705 → 913
    DUF3513; Domain of unknown function (DUF3513)
    cl17036
    Location:5 → 70
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein
Heading Accession and Version

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