spdl1 spindle apparatus coiled-coil protein 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: spdl1provided by ZNC
Official Full Name: spindle apparatus coiled-coil protein 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-070928-7
See related: Ensembl:ENSDARG00000103996 AllianceGenome:ZFIN:ZDB-GENE-070928-7
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ccdc99; id:ibd2849; zgc:171223
Summary: Predicted to enable kinetochore binding activity. Predicted to be involved in establishment of mitotic spindle orientation; mitotic metaphase plate congression; and protein localization to kinetochore. Predicted to act upstream of or within cell division and mitotic spindle assembly checkpoint signaling. Predicted to be located in nucleus. Predicted to be part of outer kinetochore. Predicted to be active in spindle pole. Is expressed in brain. Orthologous to human SPDL1 (spindle apparatus coiled-coil protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (38811842..38827422, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (38471528..38487108, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables kinetochore binding	IBA Inferred from Biological aspect of Ancestor more info
enables kinetochore binding	IEA Inferred from Electronic Annotation more info
enables kinetochore binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in establishment of mitotic spindle orientation	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of mitotic spindle orientation	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic metaphase chromosome alignment	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic metaphase chromosome alignment	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mitotic spindle assembly checkpoint signaling	IEA Inferred from Electronic Annotation more info
involved_in protein localization to kinetochore	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein localization to kinetochore	IEA Inferred from Electronic Annotation more info
involved_in protein localization to kinetochore	IEA Inferred from Electronic Annotation more info
involved_in protein localization to kinetochore	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of outer kinetochore	IBA Inferred from Biological aspect of Ancestor more info
part_of outer kinetochore	IEA Inferred from Electronic Annotation more info
part_of outer kinetochore	ISS Inferred from Sequence or Structural Similarity more info
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle pole	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: protein Spindly

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001104942.1 → NP_001098412.1 protein Spindly

See identical proteins and their annotated locations for NP_001098412.1

Status: PROVISIONAL

Source sequence(s)

BC152508

UniProtKB/Swiss-Prot

A4IGD1, A7MD70

Related

ENSDARP00000132249.1, ENSDART00000160000.2

Conserved Domains (2) summary

COG1196
Location:3 → 344

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02169
Location:312 → 457

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type