U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

l3mbtl2 L3MBTL histone methyl-lysine binding protein 2 [ Danio rerio (zebrafish) ]

Gene ID: 568473, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
l3mbtl2provided by ZNC
Official Full Name
L3MBTL histone methyl-lysine binding protein 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-8713
See related
Ensembl:ENSDARG00000056079 AllianceGenome:ZFIN:ZDB-GENE-030131-8713
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:66491; im:7137244; wu:fb04e09
Summary
Predicted to enable chromatin binding activity and methylated histone binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to act upstream of or within chromatin organization and regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in telencephalon. Orthologous to human L3MBTL2 (L3MBTL histone methyl-lysine binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See l3mbtl2 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (18970830..18988131)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (18848916..18866753)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene E1A binding protein p300 a Neighboring gene transfer RNA glutamine (anticodon CUG) Neighboring gene chondroadherin-like b Neighboring gene Ran GTPase activating protein 1b

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC66491

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
lethal(3)malignant brain tumor-like protein 2
Names
L3MBTL2, polycomb repressive complex 1 subunit
l(3)mbt-like 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200032.1 → NP_956326.1  lethal(3)malignant brain tumor-like protein 2

    See identical proteins and their annotated locations for NP_956326.1

    Status: PROVISIONAL

    Source sequence(s)
    BC057540
    UniProtKB/TrEMBL
    Q6PFI2
    Related
    ENSDARP00000072956.4, ENSDART00000078494.5
    Conserved Domains (3) summary
    smart00561
    Location:591 → 682
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    pfam02820
    Location:511 → 582
    MBT; mbt repeat
    pfam05485
    Location:4 → 89
    THAP; THAP domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    18970830..18988131
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005156155.4 → XP_005156212.1  lethal(3)malignant brain tumor-like protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005156212.1

    UniProtKB/TrEMBL
    A0A8M2B2U1, F1R4V8
    Related
    ENSDARP00000134087.1, ENSDART00000164212.3
    Conserved Domains (3) summary
    smart00561
    Location:591 → 682
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    pfam02820
    Location:511 → 582
    MBT; mbt repeat
    pfam05485
    Location:4 → 89
    THAP; THAP domain

  2. XM_005156156.4 → XP_005156213.1  lethal(3)malignant brain tumor-like protein 2 isoform X2

    See identical proteins and their annotated locations for XP_005156213.1

    UniProtKB/TrEMBL
    A0A8M2B285
    Conserved Domains (3) summary
    smart00561
    Location:590 → 681
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    pfam02820
    Location:510 → 581
    MBT; mbt repeat
    pfam05485
    Location:4 → 89
    THAP; THAP domain

  3. XM_005156157.4 → XP_005156214.1  lethal(3)malignant brain tumor-like protein 2 isoform X3

    See identical proteins and their annotated locations for XP_005156214.1

    UniProtKB/TrEMBL
    A0A8M2B270
    Conserved Domains (3) summary
    smart00561
    Location:504 → 595
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    pfam02820
    Location:424 → 495
    MBT; mbt repeat
    pfam05485
    Location:4 → 89
    THAP; THAP domain

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395301.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    185339..207346
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools