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rufy2 RUN and FYVE domain containing 2 [ Danio rerio (zebrafish) ]

Gene ID: 569096, updated on 2-Nov-2024

Summary

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Official Symbol
rufy2provided by ZNC
Official Full Name
RUN and FYVE domain containing 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-070424-66
See related
Ensembl:ENSDARG00000062019 AllianceGenome:ZFIN:ZDB-GENE-070424-66
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fj43e12; zgc:162300
Summary
Predicted to enable metal ion binding activity. Predicted to be active in cytoplasm. Orthologous to human RUFY2 (RUN and FYVE domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See rufy2 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (22876467..22907216, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (22746017..22776766, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene phenazine biosynthesis-like protein domain containing pseudogene Neighboring gene phenazine biosynthesis-like protein domain containing 2 Neighboring gene heterogeneous nuclear ribonucleoprotein H3 (2H9) Neighboring gene tetraspanin 15 Neighboring gene tachykinin receptor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. TET2 plays an essential role in erythropoiesis by regulating lineage-specific genes via DNA oxidative demethylation in a zebrafish model. Ge L, et al. Mol Cell Biol, 2014 Mar. PMID 24396069, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • KIAA0871

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RUN and FYVE domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105681.2 → NP_001099151.2  RUN and FYVE domain-containing protein 2 isoform 2

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    BC134954
    UniProtKB/TrEMBL
    A0A8M1NEB6, A4IG70
    Related
    ENSDARP00000119010.1, ENSDART00000143097.2
    Conserved Domains (3) summary
    cd15759
    Location:560 → 630
    FYVE_RUFY2; FYVE domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins
    pfam02759
    Location:69 → 192
    RUN; RUN domain
    pfam09728
    Location:234 → 559
    Taxilin; Myosin-like coiled-coil protein

  2. NM_001244919.1 → NP_001231848.1  RUN and FYVE domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001231848.1

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC155635
    UniProtKB/TrEMBL
    A4IG70, A9JRF1
    Related
    ENSDARP00000083566.4, ENSDART00000089133.6
    Conserved Domains (3) summary
    cd15759
    Location:626 → 696
    FYVE_RUFY2; FYVE domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins
    pfam02759
    Location:135 → 258
    RUN; RUN domain
    pfam09728
    Location:300 → 625
    Taxilin; Myosin-like coiled-coil protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    22876467..22907216 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005156875.5 → XP_005156932.1  RUN and FYVE domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B315
    Conserved Domains (2) summary
    pfam02759
    Location:135 → 258
    RUN; RUN domain
    cl23720
    Location:385 → 498
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394884.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    339625..367282 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395309.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    60560..91309 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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