brd2b bromodomain containing 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: brd2bprovided by ZNC
Official Full Name: bromodomain containing 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070220-1
See related: Ensembl:ENSDARG00000046087 AllianceGenome:ZFIN:ZDB-GENE-070220-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable lysine-acetylated histone binding activity. Acts upstream of or within thrombocyte differentiation. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in several structures, including head; immature eye; nervous system; ovary; and swim bladder. Human ortholog(s) of this gene implicated in B-cell lymphoma; B-lymphoblastic leukemia/lymphoma; juvenile myoclonic epilepsy; and photosensitivity disease. Orthologous to human BRD2 (bromodomain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (48714078..48725392)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (48772060..48783374)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression profiles of zebrafish brd2 paralogs support a role in vertebrate developmental patterning and morphogenesis
Title: Zebrafish brd2a and brd2b are paralogous members of the bromodomain-ET (BET) family of transcriptional coregulators that show structural and expression divergence.

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General gene information

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Markers

fk84h06.x1 (e-PCR)
- UniSTS:201618

z51029 (e-PCR), detects polymorphism
- UniSTS:238536

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables lysine-acetylated histone binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within thrombocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: bromodomain-containing protein 2b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110524.1 → NP_001103994.1 bromodomain-containing protein 2b

See identical proteins and their annotated locations for NP_001103994.1

Status: PROVISIONAL

Source sequence(s)

EU126948

UniProtKB/TrEMBL

A8CYR7

Related

ENSDARP00000124754.1, ENSDART00000150121.3

Conserved Domains (2) summary

cd05497
Location:70 → 176

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

pfam08418
Location:161 → 248

Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal