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fignl1 fidgetin-like 1 [ Danio rerio (zebrafish) ]

Gene ID: 569539, updated on 28-Oct-2024

Summary

Official Symbol
fignl1provided by ZNC
Official Full Name
fidgetin-like 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1862
See related
Ensembl:ENSDARG00000016427 AllianceGenome:ZFIN:ZDB-GENE-030131-1862
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb82h05; wu:fb82h05; wu:fj99a11; zgc:193664
Summary
Enables protein-macromolecule adaptor activity. Acts upstream of or within microtubule cytoskeleton organization. Predicted to be located in nucleus and perinuclear region of cytoplasm. Is expressed in several structures, including nervous system; solid lens vesicle; swim bladder bud; tail bud; and vertical myoseptum. Human ortholog(s) of this gene implicated in nicotine dependence. Orthologous to human FIGNL1 (fidgetin like 1). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
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Genomic context

See fignl1 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (15933142..15943934)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (15802143..15812942)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene kinesin light chain 1a Neighboring gene si:ch211-57f7.7 Neighboring gene uncharacterized LOC101883107 Neighboring gene tubulin tyrosine ligase Neighboring gene IKAROS family zinc finger 1 (Ikaros) Neighboring gene uncharacterized LOC137487381 Neighboring gene sperm microtubule inner protein 7 Neighboring gene uncharacterized LOC137487380

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables microtubule severing ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-macromolecule adaptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
fidgetin-like protein 1
NP_001122223.1
XP_005156740.1
XP_005156741.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128751.1NP_001122223.1  fidgetin-like protein 1

    See identical proteins and their annotated locations for NP_001122223.1

    Status: PROVISIONAL

    Source sequence(s)
    BC162519
    UniProtKB/TrEMBL
    A0A8M2B2R1, B3DGU1
    Related
    ENSDARP00000017944.6, ENSDART00000016294.8
    Conserved Domains (3) summary
    smart00382
    Location:420556
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:424554
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam09336
    Location:610658
    Vps4_C; Vps4 C terminal oligomerization domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    15933142..15943934
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005156684.5XP_005156741.1  fidgetin-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005156741.1

    UniProtKB/TrEMBL
    A0A8M2B2R1, B3DGU1
    Conserved Domains (3) summary
    smart00382
    Location:420556
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:424554
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam09336
    Location:610658
    Vps4_C; Vps4 C terminal oligomerization domain
  2. XM_005156683.5XP_005156740.1  fidgetin-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005156740.1

    UniProtKB/TrEMBL
    A0A8M2B2R1, B3DGU1
    Related
    ENSDARP00000117905.1, ENSDART00000131390.2
    Conserved Domains (3) summary
    smart00382
    Location:420556
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:424554
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam09336
    Location:610658
    Vps4_C; Vps4 C terminal oligomerization domain