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esyt2a extended synaptotagmin-like protein 2a [ Danio rerio (zebrafish) ]

Gene ID: 570012, updated on 2-Nov-2024

Summary

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Official Symbol
esyt2aprovided by ZNC
Official Full Name
extended synaptotagmin-like protein 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070912-588
See related
Ensembl:ENSDARG00000030824 AllianceGenome:ZFIN:ZDB-GENE-070912-588
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc01a02; wu:fc01a02; si:dkey-7l6.6
Summary
Predicted to enable calcium ion binding activity and phospholipid binding activity. Predicted to act upstream of or within endoplasmic reticulum-plasma membrane tethering and lipid transport. Predicted to be located in endoplasmic reticulum and plasma membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human ESYT2 (extended synaptotagmin 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See esyt2a in Genome Data Viewer
Location:
chromosome: 2
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (42419841..42492514, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (42570423..42643243, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene solute carrier organic anion transporter family member 5A1a Neighboring gene solute carrier organic anion transporter family member 5A1b Neighboring gene disco-interacting protein 2 homolog Cb Neighboring gene membrane-associated ring finger (C3HC4) 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolutionary genomics of plant genes encoding N-terminal-TM-C2 domain proteins and the similar FAM62 genes and synaptotagmin genes of metazoans. Craxton M. BMC Genomics, 2007 Jul 31. PMID 17672888, Free PMC Article
  2. A manual collection of Syt, Esyt, Rph3a, Rph3al, Doc2, and Dblc2 genes from 46 metazoan genomes--an open access resource for neuroscience and evolutionary biology. Craxton M. BMC Genomics, 2010 Jan 15. PMID 20078875, Free PMC Article
  3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylcholine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylethanolamine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within endoplasmic reticulum-plasma membrane tethering IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
extended synaptotagmin-2; extended synaptotagmin-2-A
Names
fam62ba

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    42419841..42492514 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005171399.5 → XP_005171456.1  extended synaptotagmin-2 isoform X4

    UniProtKB/TrEMBL
    A0A8M2BIT9, E9QCP7
    Related
    ENSDARP00000123207.1, ENSDART00000139929.3
    Conserved Domains (5) summary
    cd04030
    Location:733 → 858
    C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
    cd04050
    Location:478 → 583
    C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
    cd08391
    Location:326 → 446
    C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
    PRK13733
    Location:587 → 668
    PRK13733; conjugal transfer protein TraV; Provisional
    pfam17047
    Location:132 → 310
    SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain

  2. XM_693440.10 → XP_698532.4  extended synaptotagmin-2-A isoform X3

    UniProtKB/TrEMBL
    A0A8N7TE28, E7FF26
    Related
    ENSDARP00000025094.8, ENSDART00000009093.10
    Conserved Domains (5) summary
    cd04030
    Location:754 → 879
    C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
    cd04050
    Location:478 → 604
    C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
    cd08391
    Location:326 → 446
    C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
    PRK13733
    Location:608 → 689
    PRK13733; conjugal transfer protein TraV; Provisional
    pfam17047
    Location:132 → 310
    SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain

  3. XM_021468651.2 → XP_021324326.1  extended synaptotagmin-2 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PPZ5
    Conserved Domains (6) summary
    cd04030
    Location:767 → 892
    C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
    cd04050
    Location:478 → 617
    C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
    cd08391
    Location:326 → 446
    C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
    cl19474
    Location:621 → 702
    TraV; Type IV conjugative transfer system lipoprotein (TraV)
    cl27773
    Location:132 → 310
    SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
    cl28408
    Location:665 → 757
    UBQ; Ubiquitin homologues

  4. XM_005171397.5 → XP_005171454.1  extended synaptotagmin-2-A isoform X1

    UniProtKB/TrEMBL
    A0A8M2BIQ8
    Conserved Domains (5) summary
    cd04030
    Location:788 → 913
    C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
    cd04050
    Location:548 → 638
    C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
    cd08391
    Location:326 → 446
    C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
    PRK13733
    Location:642 → 723
    PRK13733; conjugal transfer protein TraV; Provisional
    pfam17047
    Location:132 → 310
    SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
Nucleotide Protein Strain
Heading Accession and Version

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