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aff3 AF4/FMR2 family, member 3 [ Danio rerio (zebrafish) ]

Gene ID: 570215, updated on 28-Oct-2024

Summary

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Official Symbol
aff3provided by ZNC
Official Full Name
AF4/FMR2 family, member 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-030219-193
See related
Ensembl:ENSDARG00000079575 AllianceGenome:ZFIN:ZDB-GENE-030219-193
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
id:ibd5053; si:dkey-19j7.2
Summary
Predicted to be involved in regulation of gene expression. Predicted to be located in nucleus. Predicted to be part of super elongation complex. Is expressed in notochord. Human ortholog(s) of this gene implicated in KINSSHIP syndrome. Orthologous to human AFF3 (ALF transcription elongation factor 3). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
human mouse all
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Genomic context

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See aff3 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (21490816..21526616, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (21679947..21715785, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene zinc finger, MYM-type 2 Neighboring gene M-phase phosphoprotein 8 Neighboring gene Rho guanine nucleotide exchange factor (GEF) 7a Neighboring gene uncharacterized LOC110438834

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Whole exome sequencing coupled with unbiased functional analysis reveals new Hirschsprung disease genes. Gui H, et al. Genome Biol, 2017 Mar 8. PMID 28274275, Free PMC Article
  2. Identification of vascular and hematopoietic genes downstream of etsrp by deep sequencing in zebrafish. Gomez G, et al. PLoS One, 2012. PMID 22438865, Free PMC Article
  3. A gene expression screen in zebrafish embryogenesis. Kudoh T, et al. Genome Res, 2001 Dec. PMID 11731487
  4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of super elongation complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
AF4/FMR2 family member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    21490816..21526616 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021478898.2 → XP_021334573.1  AF4/FMR2 family member 3

    UniProtKB/TrEMBL
    A0A8M3AW05
    Related
    ENSDARP00000113026.2, ENSDART00000137922.4
    Conserved Domains (1) summary
    pfam05110
    Location:730 → 1239
    AF-4; AF-4 proto-oncoprotein

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394750.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    50761..86561 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009304671.3 → XP_009302946.1  AF4/FMR2 family member 3

    UniProtKB/TrEMBL
    A0A8M3AW05
    Conserved Domains (1) summary
    pfam05110
    Location:730 → 1239
    AF-4; AF-4 proto-oncoprotein
Nucleotide Protein Strain
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