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galnt2 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 [ Danio rerio (zebrafish) ]

Gene ID: 570248, updated on 2-Nov-2024

Summary

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Official Symbol
galnt2provided by ZNC
Official Full Name
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-041111-110
See related
Ensembl:ENSDARG00000003829 AllianceGenome:ZFIN:ZDB-GENE-041111-110
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7140357; si:dkey-162b3.1
Summary
Predicted to enable polypeptide N-acetylgalactosaminyltransferase activity. Acts upstream of or within fin regeneration and regulation of bone mineralization. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to human GALNT2 (polypeptide N-acetylgalactosaminyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See galnt2 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (24068577..24218795, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (23938127..24088348, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene component of oligomeric golgi complex 2 Neighboring gene piggyBac transposable element derived 5 Neighboring gene URB2 ribosome biogenesis homolog Neighboring gene ATP-binding cassette, sub-family B (MDR/TAP), member 10 Neighboring gene actin alpha 1, skeletal muscle b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Giantin-knockout models reveal a feedback loop between Golgi function and glycosyltransferase expression. Stevenson NL, et al. J Cell Sci, 2017 Dec 15. PMID 29093022, Free PMC Article
  2. Genetic compensation triggered by actin mutation prevents the muscle damage caused by loss of actin protein. Sztal TE, et al. PLoS Genet, 2018 Feb. PMID 29420541, Free PMC Article
  3. A new evolutionary model for the vertebrate actin family including two novel groups. Witjes L, et al. Mol Phylogenet Evol, 2019 Dec. PMID 31560986
  4. A novel inducible mutagenesis screen enables to isolate and clone both embryonic and adult zebrafish mutants. Ma Z, et al. Sci Rep, 2017 Sep 4. PMID 28871129, Free PMC Article
  5. An intestinal cell type in zebrafish is the nexus for the SARS-CoV-2 receptor and the Renin-Angiotensin-Aldosterone System that contributes to COVID-19 comorbidities. Postlethwait JH, et al. bioRxiv, 2020 Sep 2. PMID 32908984, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables hexosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within fin regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of bone mineralization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
polypeptide N-acetylgalactosaminyltransferase 2
NP_001121823.1
XP_009305623.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128351.1 → NP_001121823.1  polypeptide N-acetylgalactosaminyltransferase 2

    Status: PROVISIONAL

    Source sequence(s)
    CR762497
    UniProtKB/TrEMBL
    A0A8M1NJY4, B0V0U4
    Related
    ENSDARP00000116568.1, ENSDART00000136217.2
    Conserved Domains (3) summary
    cd02510
    Location:127 → 422
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    cd00161
    Location:444 → 553
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:434 → 551
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    24068577..24218795 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009307348.4 → XP_009305623.1  polypeptide N-acetylgalactosaminyltransferase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M3B826
    Conserved Domains (4) summary
    cd02510
    Location:127 → 422
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    cd00161
    Location:444 → 559
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:434 → 557
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    pfam13641
    Location:127 → 351
    Glyco_tranf_2_3; Glycosyltransferase like family 2
Nucleotide Protein Strain
Heading Accession and Version

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