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apoa4b.2 apolipoprotein A-IV b, tandem duplicate 2 [ Danio rerio (zebrafish) ]

Gene ID: 570354, updated on 17-Aug-2024

Summary

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Official Symbol
apoa4b.2provided by ZNC
Official Full Name
apolipoprotein A-IV b, tandem duplicate 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3143
See related
Ensembl:ENSDARG00000020866 AllianceGenome:ZFIN:ZDB-GENE-030131-3143
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc28d04; wu:fc10a03; wu:fc28d04; zgc:194131
Summary
Predicted to enable lipid binding activity. Predicted to act upstream of or within lipid transport and lipoprotein metabolic process. Predicted to be located in extracellular region. Is expressed in ball; extension; intestine; yolk; and yolk syncytial layer. Human ortholog(s) of this gene implicated in Alzheimer's disease; colitis; myocardial infarction; and ulcerative colitis. Orthologous to human APOA4 (apolipoprotein A4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 16
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (23947078..23948538)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (24032187..24033399)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene si:dkey-7f3.14 Neighboring gene apolipoprotein A-IV b, tandem duplicate 3 Neighboring gene apolipoprotein Eb Neighboring gene apolipoprotein C-I

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Parental micronutrient deficiency distorts liver DNA methylation and expression of lipid genes associated with a fatty-liver-like phenotype in offspring. Skjærven KH, et al. Sci Rep, 2018 Feb 14. PMID 29445184, Free PMC Article
  2. Starvation causes changes in the intestinal transcriptome and microbiome that are reversed upon refeeding. Jawahar J, et al. BMC Genomics, 2022 Mar 22. PMID 35317738, Free PMC Article
  3. Zebrafish as a model for apolipoprotein biology: comprehensive expression analysis and a role for ApoA-IV in regulating food intake. Otis JP, et al. Dis Model Mech, 2015 Mar. PMID 25633982, Free PMC Article
  4. Imazalil exposure induces gut microbiota dysbiosis and hepatic metabolism disorder in zebrafish. Jin C, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2017 Nov. PMID 28888875
  5. Parental vitamin deficiency affects the embryonic gene expression of immune-, lipid transport- and apolipoprotein genes. Skjærven KH, et al. Sci Rep, 2016 Oct 12. PMID 27731423, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cholesterol transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylcholine-sterol O-acyltransferase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in acylglycerol homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cholesterol efflux IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cholesterol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipoprotein metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid efflux IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chylomicron IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of high-density lipoprotein particle IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of low-density lipoprotein particle IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of very-low-density lipoprotein particle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
apolipoprotein A-IV b, tandem duplicate 2; apolipoprotein A-IV-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128758.1 → NP_001122230.1  apolipoprotein A-IV b, tandem duplicate 2 precursor

    See identical proteins and their annotated locations for NP_001122230.1

    Status: PROVISIONAL

    Source sequence(s)
    BC162715
    UniProtKB/TrEMBL
    B3DHC5, B3DHC6
    Related
    ENSDARP00000093966.3, ENSDART00000103190.5
    Conserved Domains (1) summary
    pfam01442
    Location:71 → 234
    Apolipoprotein; Apolipoprotein A1/A4/E domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    23947078..23948538
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021466732.1 → XP_021322407.1  apolipoprotein A-IV-like isoform X1

    UniProtKB/TrEMBL
    A0A8M9NZC6
    Conserved Domains (1) summary
    pfam01442
    Location:130 → 293
    Apolipoprotein; Apolipoprotein A1/A4/E domain

  2. XM_021466733.1 → XP_021322408.1  apolipoprotein A-IV-like isoform X2

    UniProtKB/TrEMBL
    B3DHC5, B3DHC6
    Related
    ENSDARP00000114649.1, ENSDART00000142168.2
    Conserved Domains (1) summary
    pfam01442
    Location:71 → 234
    Apolipoprotein; Apolipoprotein A1/A4/E domain
Nucleotide Protein Strain
Heading Accession and Version

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