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prkag2a protein kinase, AMP-activated, gamma 2 non-catalytic subunit a [ Danio rerio (zebrafish) ]

Gene ID: 570761, updated on 18-Sep-2024

Summary

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Official Symbol
prkag2aprovided by ZNC
Official Full Name
protein kinase, AMP-activated, gamma 2 non-catalytic subunit aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060929-160
See related
Ensembl:ENSDARG00000012625 AllianceGenome:ZFIN:ZDB-GENE-060929-160
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:153329
Summary
Predicted to enable AMP binding activity; protein kinase binding activity; and protein kinase regulator activity. Predicted to be involved in cellular response to glucose starvation; protein phosphorylation; and regulation of catalytic activity. Predicted to act upstream of or within regulation of protein serine/threonine kinase activity. Predicted to be part of nucleotide-activated protein kinase complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Wolff-Parkinson-White syndrome; glycogen storage disease; hypertrophic cardiomyopathy 6; and lethal congenital glycogen storage disease of heart. Orthologous to human PRKAG2 (protein kinase AMP-activated non-catalytic subunit gamma 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See prkag2a in Genome Data Viewer
Location:
chromosome: 24
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (28252520..28381430, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (28173361..28302253, complement)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 4I1, like Neighboring gene uncharacterized LOC110438353 Neighboring gene SH3-domain GRB2-like endophilin B1a Neighboring gene negative regulator of reactive oxygen species

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Different physiological roles of insulin receptors in mediating nutrient metabolism in zebrafish. Yang BY, et al. Am J Physiol Endocrinol Metab, 2018 Jul 1. PMID 29351486
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables AMP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to glucose starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of carbon utilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nucleotide-activated protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
5'-AMP-activated protein kinase subunit gamma-2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077179.2 → NP_001070647.2  5'-AMP-activated protein kinase subunit gamma-2a isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5'-terminal exon and a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    CU855779, FP017236
    UniProtKB/TrEMBL
    A0A8M1NBF3, F8W5P9
    Related
    ENSDARP00000125018.1, ENSDART00000148618.3

  2. NM_001328430.1 → NP_001315359.1  5'-AMP-activated protein kinase subunit gamma-2a isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    CU694811, CU855779, FP017236
    UniProtKB/TrEMBL
    A0A8M1PAB4, F1QJ49
    Related
    ENSDARP00000109004.3, ENSDART00000129174.4
    Conserved Domains (3) summary
    COG0517
    Location:300 → 416
    CBS; CBS domain [Signal transduction mechanisms]
    cd04618
    Location:143 → 272
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:300 → 418
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    28252520..28381430 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009297511.4 → XP_009295786.1  5'-AMP-activated protein kinase subunit gamma-2a isoform X2

    UniProtKB/TrEMBL
    A0A8M3APB3
    Conserved Domains (3) summary
    COG0517
    Location:407 → 523
    CBS; CBS domain [Signal transduction mechanisms]
    cd04618
    Location:250 → 379
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:407 → 525
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

  2. XM_021470213.2 → XP_021325888.1  5'-AMP-activated protein kinase subunit gamma-2a isoform X1

    UniProtKB/TrEMBL
    A0A8M9PG44
    Conserved Domains (3) summary
    cd04618
    Location:250 → 379
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:407 → 525
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cl25836
    Location:45 → 160
    Retinal; Retinal protein

  3. XM_068217101.1 → XP_068073202.1  5'-AMP-activated protein kinase subunit gamma-2a isoform X3

  4. XM_068217102.1 → XP_068073203.1  5'-AMP-activated protein kinase subunit gamma-2a isoform X4

RNA

  1. XR_659834.4 RNA Sequence

  2. XR_011008556.1 RNA Sequence

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395180.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    2594..3044 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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