pggt1b protein geranylgeranyltransferase type I, beta subunit [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pggt1bprovided by ZNC
Official Full Name: protein geranylgeranyltransferase type I, beta subunitprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050913-85
See related: Ensembl:ENSDARG00000103464 AllianceGenome:ZFIN:ZDB-GENE-050913-85
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:114070
Summary: Predicted to enable protein geranylgeranyltransferase activity. Predicted to contribute to CAAX-protein geranylgeranyltransferase activity. Acts upstream of or within blood vessel maturation. Predicted to be part of CAAX-protein geranylgeranyltransferase complex. Orthologous to human PGGT1B (protein geranylgeranyltransferase type I subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (411977..418998, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (411977..418998, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

G41603 (e-PCR)
- UniSTS:16227

Z1634 (e-PCR)
- UniSTS:13211

z13288 (e-PCR), detects polymorphism
- UniSTS:238240

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
contributes_to CAAX-protein geranylgeranyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables CAAX-protein geranylgeranyltransferase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables prenyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein geranylgeranyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein prenyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood vessel maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein geranylgeranylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of CAAX-protein geranylgeranyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CAAX-protein geranylgeranyltransferase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: geranylgeranyl transferase type-1 subunit beta

Names: ggt1b

NP_001025426.1

EC 2.5.1.59

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030255.2 → NP_001025426.1 geranylgeranyl transferase type-1 subunit beta

See identical proteins and their annotated locations for NP_001025426.1

Status: PROVISIONAL

Source sequence(s)

BC097132

UniProtKB/TrEMBL

Q4V8Z9

Related

ENSDARP00000136678.1, ENSDART00000166683.1

Conserved Domains (2) summary

COG5029
Location:10 → 331

CAL1; Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism]

cd02895
Location:11 → 321

GGTase-I; Geranylgeranyltransferase types I (GGTase-I)-like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-I s are a subgroup of the protein prenyltransferase family of lipid-modifying enzymes ...