glis3 GLIS family zinc finger 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: glis3provided by ZNC
Official Full Name: GLIS family zinc finger 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-070112-2232
See related: Ensembl:ENSDARG00000069726 AllianceGenome:ZFIN:ZDB-GENE-070112-2232
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fa55a05; zgc:158249
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in smoothened signaling pathway and thyroid gland development. Acts upstream of or within glucose homeostasis; pancreas regeneration; and type B pancreatic cell development. Predicted to be active in nucleus. Is expressed in several structures, including brain; endoderm; otic vesicle; pectoral fin bud; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in neonatal diabetes mellitus with congenital hypothyroidism. Orthologous to human GLIS3 (GLIS family zinc finger 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 10

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (643684..690223, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (628141..674274, complement)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glis3 as a Critical Regulator of Thyroid Primordium Specification.
Title: Glis3 as a Critical Regulator of Thyroid Primordium Specification.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pancreas regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thyroid gland development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within type B pancreatic cell development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: zinc finger protein GLIS3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080607.2 → NP_001074076.2 zinc finger protein GLIS3

Status: VALIDATED

Source sequence(s)

BC129173, CA470456, CD585814, CU468737, DV591821

UniProtKB/TrEMBL

A0A8M1NCX8, A1L1Q6, F1QB13

Related

ENSDARP00000118619.1, ENSDART00000142833.2

Conserved Domains (2) summary

sd00017
Location:469 → 491

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:483 → 510

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007121.7 Reference GRCz11 Primary Assembly

Range

643684..690223 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009305042.4 → XP_009303317.1 zinc finger protein GLIS3 isoform X2

UniProtKB/TrEMBL

A0A8M3B5Y0, A1L1Q6

Conserved Domains (2) summary

sd00017
Location:468 → 490

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:482 → 509

zf-H2C2_2; Zinc-finger double domain
XM_021479194.2 → XP_021334869.1 zinc finger protein GLIS3 isoform X3

UniProtKB/TrEMBL

A0A8M9Q669, A1L1Q6

Conserved Domains (2) summary

COG5189
Location:458 → 552

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:469 → 491

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_017357981.3 → XP_017213470.1 zinc finger protein GLIS3 isoform X1

UniProtKB/TrEMBL

A0A8M6Z1B7, A1L1Q6
XM_021479193.2 → XP_021334868.1 zinc finger protein GLIS3 isoform X3

UniProtKB/TrEMBL

A0A8M9Q669, A1L1Q6

Conserved Domains (2) summary

COG5189
Location:458 → 552

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:469 → 491

ZF_C2H2; C2H2 Zn finger [structural motif]