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efhd2 EF-hand domain family, member D2 [ Danio rerio (zebrafish) ]

Gene ID: 571114, updated on 2-Nov-2024

Summary

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Official Symbol
efhd2provided by ZNC
Official Full Name
EF-hand domain family, member D2provided by ZNC
Primary source
ZFIN:ZDB-GENE-060531-152
See related
Ensembl:ENSDARG00000055759 AllianceGenome:ZFIN:ZDB-GENE-060531-152
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fb80e07; si:dkey-72l14.9
Summary
Predicted to enable calcium ion binding activity. Orthologous to human EFHD2 (EF-hand domain family member D2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See efhd2 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (25818622..25846188, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (25799483..25827049, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, L type, alpha 1S subunit, b Neighboring gene TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor Neighboring gene opsin 7, group member c Neighboring gene transmembrane protein 115

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Is your "gene of interest" interesting? Kiefer JC. Dev Dyn, 2007 Oct. PMID 17849447
  2. Fraternal twins: Swiprosin-1/EFhd2 and Swiprosin-2/EFhd1, two homologous EF-hand containing calcium binding adaptor proteins with distinct functions. Dütting S, et al. Cell Commun Signal, 2011 Jan 18. PMID 21244694, Free PMC Article
  3. Differential recruitment of co-regulatory proteins to the human estrogen receptor 1 in response to xenoestrogens. Smith LC, et al. Comp Biochem Physiol Part D Genomics Proteomics, 2016 Sep. PMID 27156127, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
EF-hand domain-containing protein D2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001326493.1 → NP_001313422.1  EF-hand domain-containing protein D2

    Status: VALIDATED

    Source sequence(s)
    BX784025, CK026993, EH591880
    UniProtKB/TrEMBL
    A2RUX3, Q1LVD7
    Related
    ENSDARP00000108177.2, ENSDART00000128829.3
    Conserved Domains (2) summary
    cd00051
    Location:89 → 147
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:90 → 147
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    25818622..25846188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001045211.2: Suppressed sequence

    Description
    NM_001045211.2: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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