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gsdf gonadal somatic cell derived factor [ Danio rerio (zebrafish) ]

Gene ID: 571289, updated on 17-Sep-2024

Summary

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Official Symbol
gsdfprovided by ZNC
Official Full Name
gonadal somatic cell derived factorprovided by ZNC
Primary source
ZFIN:ZDB-GENE-101029-3
See related
Ensembl:ENSDARG00000075301 AllianceGenome:ZFIN:ZDB-GENE-101029-3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable growth factor activity. Acts upstream of or within oocyte maturation. Is expressed in granulosa cell and reproductive system. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See gsdf in Genome Data Viewer
Location:
chromosome: 21
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (198260..205218)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (11830..20561)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene kelch-like family member 8 Neighboring gene AF4/FMR2 family, member 1 Neighboring gene protein phosphatase with EF-hand domain 2b Neighboring gene serine/threonine-protein phosphatase with EF-hands 2 Neighboring gene nucleoporin 54

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The proximal promoter region of the zebrafish gsdf gene is sufficient to mimic the spatio-temporal expression pattern of the endogenous gene in Sertoli and granulosa cells. Gautier A, et al. Biol Reprod, 2011 Dec. PMID 21816849
  2. GFP expression pattern in pituitary and gonads under the control of nuclear progesterone receptor promoter in transgenic zebrafish. Huang J, et al. Dev Dyn, 2020 Nov. PMID 32506585
  3. The transcriptome of the newt Cynops orientalis provides new insights into evolution and function of sexual gene networks in sarcopterygians. Biscotti MA, et al. Sci Rep, 2020 Mar 25. PMID 32214214, Free PMC Article
  4. Optimization of the Gal4/UAS transgenic tools in zebrafish. Zhang Y, et al. Appl Microbiol Biotechnol, 2019 Feb. PMID 30613898
  5. Application of dead end-knockout zebrafish as recipients of germ cell transplantation. Li Q, et al. Mol Reprod Dev, 2017 Oct. PMID 28731265

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In zebrafish, gsdf regulates ovarian follicle maturation and expression of genes for steroid biosynthesis, obesity, diabetes, and female fertility, leading to ovarian and extra-ovarian phenotypes that mimic human polycystic ovarian syndrome (PCOS)
    Title: Gonadal soma controls ovarian follicle proliferation through Gsdf in zebrafish.
  2. evolutionarily conserved DNA motifs may be involved in Sertoli and granulosa cell-specific expression
    Title: The proximal promoter region of the zebrafish gsdf gene is sufficient to mimic the spatio-temporal expression pattern of the endogenous gene in Sertoli and granulosa cells.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within oocyte maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
gonadal somatic cell derived factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114668.1 → NP_001108140.1  gonadal somatic cell derived factor precursor

    Status: PROVISIONAL

    Source sequence(s)
    EU378916
    UniProtKB/TrEMBL
    A0A2R8QCF5, B0ZE98, G1CSU3
    Related
    ENSDARP00000149345.1, ENSDART00000193485.1
    Conserved Domains (1) summary
    cl02510
    Location:85 → 157
    TGF_beta; Transforming growth factor beta like domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    198260..205218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005173843.5 → XP_005173900.1  gonadal somatic cell derived factor isoform X2

    UniProtKB/TrEMBL
    A0A0R4IHC8, A0A8M2BLI7
    Related
    ENSDARP00000134025.2, ENSDART00000163696.2
    Conserved Domains (1) summary
    cl02510
    Location:84 → 156
    TGF_beta; Transforming growth factor beta like domain

  2. XM_003200793.6 → XP_003200841.1  gonadal somatic cell derived factor isoform X1

    UniProtKB/TrEMBL
    A0A8M1RP53
Nucleotide Protein Strain
Heading Accession and Version

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