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marco macrophage receptor with collagenous structure [ Danio rerio (zebrafish) ]

Gene ID: 571584, updated on 18-Sep-2024

Summary

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Official Symbol
marcoprovided by ZNC
Official Full Name
macrophage receptor with collagenous structureprovided by ZNC
Primary source
ZFIN:ZDB-GENE-120514-2
See related
Ensembl:ENSDARG00000059294 AllianceGenome:ZFIN:ZDB-GENE-120514-2
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to be an extracellular matrix structural constituent. Acts upstream of or within defense response to bacterium and phagocytosis. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to human MARCO (macrophage receptor with collagenous structure). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See marco in Genome Data Viewer
Location:
chromosome: 9
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (795678..813533, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (796045..813953, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101883921 Neighboring gene engrailed homeobox 1a Neighboring gene complement component 1, q subcomponent-like 2 Neighboring gene putative C-type lectin domain family 20 member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish as a Vertebrate Model for Studying Nodavirus Infections. Lama R, et al. Front Immunol, 2022. PMID 35401537, Free PMC Article
  2. Loss of the homologous recombination gene rad51 leads to Fanconi anemia-like symptoms in zebrafish. Botthof JG, et al. Proc Natl Acad Sci U S A, 2017 May 30. PMID 28512217, Free PMC Article
  3. Comparative transcriptome analysis of zebrafish (Danio rerio) brain and spleen infected with spring viremia of carp virus (SVCV). Wang Y, et al. Fish Shellfish Immunol, 2017 Oct. PMID 28757199
  4. Stabilin 1 and 2 are important regulators for cellular uptake of apolipoprotein B-containing lipoproteins in zebrafish. Verwilligen RAF, et al. Atherosclerosis, 2022 Apr. PMID 35247629
  5. A csf1rb mutation uncouples two waves of microglia development in zebrafish. Ferrero G, et al. Development, 2021 Jan 11. PMID 33298459

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phagocytosis of mycobacteria by zebrafish macrophages is dependent on the scavenger receptor Marco, a key control factor of pro-inflammatory signaling.
    Title: Phagocytosis of mycobacteria by zebrafish macrophages is dependent on the scavenger receptor Marco, a key control factor of pro-inflammatory signalling.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phagocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
macrophage receptor MARCO

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    795678..813533 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009304404.4 → XP_009302679.1  macrophage receptor MARCO isoform X3

    UniProtKB/TrEMBL
    A0A8M3BC80, F1QU19
    Related
    ENSDARP00000076803.4, ENSDART00000082368.5
    Conserved Domains (3) summary
    pfam01391
    Location:159 → 226
    Collagen; Collagen triple helix repeat (20 copies)
    smart00202
    Location:355 → 449
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:360 → 450
    SRCR; Scavenger receptor cysteine-rich domain

  2. XM_068223529.1 → XP_068079630.1  macrophage receptor MARCO isoform X6

  3. XM_068223528.1 → XP_068079629.1  macrophage receptor MARCO isoform X5

    Related
    ENSDARP00000144174.1, ENSDART00000174793.2

  4. XM_009304405.4 → XP_009302680.1  macrophage receptor MARCO isoform X4

    UniProtKB/TrEMBL
    A0A286YAI0, A0A8M3AVP8
    Conserved Domains (3) summary
    pfam01391
    Location:159 → 226
    Collagen; Collagen triple helix repeat (20 copies)
    smart00202
    Location:355 → 449
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:360 → 450
    SRCR; Scavenger receptor cysteine-rich domain

  5. XM_068223527.1 → XP_068079628.1  macrophage receptor MARCO isoform X2

  6. XM_005169122.5 → XP_005169179.1  macrophage receptor MARCO isoform X1

    UniProtKB/TrEMBL
    A0A8M2BH24
    Conserved Domains (3) summary
    pfam01391
    Location:177 → 236
    Collagen; Collagen triple helix repeat (20 copies)
    smart00202
    Location:441 → 535
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:446 → 536
    SRCR; Scavenger receptor cysteine-rich domain
Nucleotide Protein Strain
Heading Accession and Version

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