gja9a gap junction protein alpha 9a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gja9aprovided by ZNC
Official Full Name: gap junction protein alpha 9aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-010619-3
See related: AllianceGenome:ZFIN:ZDB-GENE-010619-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cx55.5
Summary: Enables gap junction hemi-channel activity. Acts upstream of or within sensory perception of light stimulus. Located in gap junction. Is expressed in central nervous system; heart; liver; muscle; and retina. Orthologous to human GJA9 (gap junction protein alpha 9). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: chromosome: 16

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (33157067..33159616)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (33199445..33207455)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study found that all horizontal cells showed Cx55.5 promoter activity.
Title: Specific connectivity between photoreceptors and horizontal cells in the zebrafish retina.
Cx55.5 contributes to horizontal cell hemichannel currents at the first visual synapse, and may have a regulatory function enhancing the amplitude of hemichannel currents.
Title: Physiological and molecular characterization of connexin hemichannels in zebrafish retinal horizontal cells.
Two stretches of polypyrimidine tracts designated PPT1 and PPT2 which influence the IRES activity of cx55.5 protein were identified.
Title: Characterization of the internal IRES element of the zebrafish connexin55.5 reveals functional implication of the polypyrimidine tract binding protein.
These results offer the first in vivo demonstration of the HC-specific activities of the Cx52.6 and Cx55.5 promoters. Furthermore, these data provide the first proof at the protein level for retinal HC-specific connexins in the zebrafish.
Title: Retinal horizontal cell-specific promoter activity and protein expression of zebrafish connexin 52.6 and connexin 55.5.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables gap junction hemi-channel activity	IDA Inferred from Direct Assay more info	PubMed
enables gap junction hemi-channel activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell communication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sensory perception of light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
part_of connexin complex	IEA Inferred from Electronic Annotation more info
located_in gap junction	IDA Inferred from Direct Assay more info	PubMed
located_in gap junction	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: gap junction alpha-9 protein

Names: connexin 55.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131812.1 → NP_571887.1 gap junction alpha-9 protein

See identical proteins and their annotated locations for NP_571887.1

Status: PROVISIONAL

Source sequence(s)

AF304048

UniProtKB/TrEMBL

Q9DF30

Conserved Domains (1) summary

pfam00029
Location:3 → 234

Connexin; Connexin

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007127.7 Reference GRCz11 Primary Assembly

Range

33157067..33159616

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021466745.2 → XP_021322420.1 gap junction alpha-9 protein isoform X1

UniProtKB/TrEMBL

Q9DF30

Conserved Domains (1) summary

pfam00029
Location:3 → 234

Connexin; Connexin