rhof ras homolog family member F [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rhofprovided by ZNC
Official Full Name: ras homolog family member Fprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-280
See related: Ensembl:ENSDARG00000054389 AllianceGenome:ZFIN:ZDB-GENE-050522-280
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:112017
Summary: Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including actin filament organization; regulation of actin cytoskeleton organization; and signal transduction. Predicted to act upstream of or within small GTPase-mediated signal transduction. Predicted to be active in cytosol and plasma membrane. Is expressed in macrophage and yolk syncytial layer. Orthologous to several human genes including RHOF (ras homolog family member F, filopodia associated). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 10

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (41969428..41980797, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (42141048..42152417, complement)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: rho-related GTP-binding protein RhoF

Names: ras homolog gene family, member F

NP_001018478.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001020642.1 → NP_001018478.1 rho-related GTP-binding protein RhoF

See identical proteins and their annotated locations for NP_001018478.1

Status: PROVISIONAL

Source sequence(s)

BC095646

UniProtKB/TrEMBL

Q502M0

Related

ENSDARP00000071047.5, ENSDART00000076575.6

Conserved Domains (2) summary

smart00174
Location:19 → 186

RHO; Rho (Ras homology) subfamily of Ras-like small GTPases

cl21455
Location:17 → 209

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases