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zp3.2 zona pellucida glycoprotein 3, tandem duplicate 2 [ Danio rerio (zebrafish) ]

Gene ID: 574007, updated on 2-Nov-2024

Summary

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Official Symbol
zp3.2provided by ZNC
Official Full Name
zona pellucida glycoprotein 3, tandem duplicate 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-050626-121
See related
Ensembl:ENSDARG00000115457 AllianceGenome:ZFIN:ZDB-GENE-050626-121
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zpc2; zp3.3; zgc:114017
Summary
Predicted to enable acrosin binding activity. Predicted to be involved in binding activity of sperm to zona pellucida; egg coat formation; and positive regulation of acrosome reaction. Predicted to be located in egg coat; extracellular region; and plasma membrane. Predicted to be active in extracellular matrix. Orthologous to several human genes including ZP3 (zona pellucida glycoprotein 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See zp3.2 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (2587405..2590245, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (2411019..2413859, complement)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene zona pellucida glycoprotein 3, tandem duplicate 1 Neighboring gene zona pellucida sperm-binding protein 3-like Neighboring gene zona pellucida glycoprotein 3 Neighboring gene protein tyrosine phosphatase non-receptor type 21

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Transfer of the zp3a gene results in changes in egg adhesiveness and buoyancy in transgenic zebrafish. Cao YQ, et al. Zool Res, 2023 Mar 18. PMID 36650065, Free PMC Article
  2. Zebrafish eggs used as bioreactors for the production of bioactive tilapia insulin-like growth factors. Hu SY, et al. Transgenic Res, 2011 Feb. PMID 20373020
  3. The roles of follistatin 1 in regulation of zebrafish fecundity and sexual differentiation. Jiang N, et al. Biol Reprod, 2012 Sep. PMID 22699484
  4. Regulation of zebrafish zona pellucida gene activity in developing oocytes. Mold DE, et al. Biol Reprod, 2009 Jul. PMID 19299318
  5. Nitroreductase-mediated gonadal dysgenesis for infertility control of genetically modified zebrafish. Hu SY, et al. Mar Biotechnol (NY), 2010 Oct. PMID 19941022

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables acrosin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of egg coat IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in binding of sperm to zona pellucida IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in egg coat formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of acrosome reaction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in egg coat IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zona pellucida sperm-binding protein 3.2
Names
zona pellucida glycoprotein 3.2
zona pellucida glycoprotein 3.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025186.1 → NP_001020357.1  zona pellucida sperm-binding protein 3.2 precursor

    See identical proteins and their annotated locations for NP_001020357.1

    Status: PROVISIONAL

    Source sequence(s)
    BC097085
    UniProtKB/TrEMBL
    Q4QRF0
    Related
    ENSDARP00000154817.1, ENSDART00000185711.1
    Conserved Domains (2) summary
    smart00241
    Location:116 → 371
    ZP; Zona pellucida (ZP) domain
    pfam00100
    Location:236 → 370
    Zona_pellucida; Zona pellucida-like domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    2587405..2590245 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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