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ZNF319 zinc finger protein 319 [ Homo sapiens (human) ]

Gene ID: 57567, updated on 2-Nov-2024

Summary

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Official Symbol
ZNF319provided by HGNC
Official Full Name
zinc finger protein 319provided by HGNC
Primary source
HGNC:HGNC:13644
See related
Ensembl:ENSG00000166188 AllianceGenome:HGNC:13644
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZFP319
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in spleen (RPKM 3.4), thyroid (RPKM 3.3) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See ZNF319 in Genome Data Viewer
Location:
16q21
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (57994676..58000672, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (63789961..63795961, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (58028580..58034576, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57917491-57918038 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57918039-57918586 Neighboring gene cyclic nucleotide gated channel subunit beta 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7538 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57945302-57946008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57972707-57973534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57973535-57974362 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57998489-57998988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10918 Neighboring gene sperm microtubule inner protein 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10919 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7539 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7540 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_43822 Neighboring gene Sharpr-MPRA regulatory region 3942 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10920 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:58046115-58046647 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:58046648-58047179 Neighboring gene U6 snRNA biogenesis phosphodiesterase 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:58058267-58058854 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:58058855-58059440 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:58059673-58060222 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:58060773-58061322 Neighboring gene matrix metallopeptidase 15 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:58119688-58120378 Neighboring gene TIPIN pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genome-wide CRISPR/Cas9 knockout screening uncovers ZNF319 as a novel tumor suppressor critical for breast cancer metastasis. Wang L, et al. Biochem Biophys Res Commun, 2022 Jan 22. PMID 34902746
  2. Overexpression of a novel zinc-finger protein induces apoptosis in NIH3T3 fibroblasts. Laub F, et al. Genomics, 2000 Dec 15. PMID 11161788
  3. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2000 Feb 28. PMID 10718198
  4. Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC. Zeng H, et al. Elife, 2019 Nov 19. PMID 31741433, Free PMC Article
  5. ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold. Yang W, et al. Theranostics, 2022. PMID 36168627, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genome-wide CRISPR/Cas9 knockout screening uncovers ZNF319 as a novel tumor suppressor critical for breast cancer metastasis.
    Title: Genome-wide CRISPR/Cas9 knockout screening uncovers ZNF319 as a novel tumor suppressor critical for breast cancer metastasis.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC126816

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 319

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001384365.1 → NP_001371294.1  zinc finger protein 319

    Status: VALIDATED

    Source sequence(s)
    AC010543
    Consensus CDS
    CCDS32462.1
    UniProtKB/Swiss-Prot
    Q52LH8, Q9P2F9
    Conserved Domains (4) summary
    COG5048
    Location:192 → 349
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:425 → 505
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:204 → 224
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:500 → 525
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001384366.1 → NP_001371295.1  zinc finger protein 319

    Status: VALIDATED

    Source sequence(s)
    AC010543
    Consensus CDS
    CCDS32462.1
    UniProtKB/Swiss-Prot
    Q52LH8, Q9P2F9
    Conserved Domains (4) summary
    COG5048
    Location:192 → 349
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:425 → 505
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:204 → 224
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:500 → 525
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001384367.1 → NP_001371296.1  zinc finger protein 319

    Status: VALIDATED

    Source sequence(s)
    AC010543
    Consensus CDS
    CCDS32462.1
    UniProtKB/Swiss-Prot
    Q52LH8, Q9P2F9
    Conserved Domains (4) summary
    COG5048
    Location:192 → 349
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:425 → 505
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:204 → 224
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:500 → 525
    zf-H2C2_2; Zinc-finger double domain

  4. NM_020807.3 → NP_065858.1  zinc finger protein 319

    See identical proteins and their annotated locations for NP_065858.1

    Status: VALIDATED

    Source sequence(s)
    AC010543
    Consensus CDS
    CCDS32462.1
    UniProtKB/Swiss-Prot
    Q52LH8, Q9P2F9
    Related
    ENSP00000299237.2, ENST00000299237.3
    Conserved Domains (4) summary
    COG5048
    Location:192 → 349
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:425 → 505
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:204 → 224
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:500 → 525
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    57994676..58000672 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    63789961..63795961 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9P2F9.2 GenPept UniProtKB/Swiss-Prot:Q9P2F9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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