notch3 notch receptor 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: notch3provided by ZNC
Official Full Name: notch receptor 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-000329-5
See related: Ensembl:ENSDARG00000052139 AllianceGenome:ZFIN:ZDB-GENE-000329-5
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: notch5; fa14b08; wu:fa14b08
Summary: Predicted to enable Notch binding activity. Acts upstream of or within several processes, including animal organ development; blood vessel development; and neurogenesis. Predicted to be located in nucleus and plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including digestive system; mesoderm; nervous system; pleuroperitoneal region; and vasculature. Human ortholog(s) of this gene implicated in CADASIL 1; infantile myofibromatosis; and lateral meningocele syndrome. Orthologous to human NOTCH3 (notch receptor 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (53529714..53559408, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (53275051..53304745, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results demonstrate that quiescence and stemness are molecularly distinct outputs of Notch3 signalling, and identify Hey1 as a major Notch3 effector controlling NSC stemness in the vertebrate adult brain.
Title: Neural stem cell quiescence and stemness are molecularly distinct outputs of the Notch3 signalling cascade in the vertebrate adult brain.
The Notch3 receptor is required earlier within the developing somite to regulate hematopoietic stem cell (HSC) emergence in a non-cell-autonomous manner.
Title: Discrete Notch signaling requirements in the specification of hematopoietic stem cells.
90 % of proliferating radial glia express notch1a, notch1b and notch3. In contrast, the proliferating non-glial populations of the dorsal telencephalon and hypothalamus rarely express notch3 and about half express notch1a/1b.
Title: Notch receptor expression in neurogenic regions of the adult zebrafish brain.
Notch3 regulates oligodendrocyte precursor cells development and mbp gene expression in larvae, and maintains vascular integrity in adults.
Title: notch3 is essential for oligodendrocyte development and vascular integrity in zebrafish.
new role for Notch signaling in brain vascular development whereby Notch3 signaling promotes expansion of the brain pericyte population
Title: Notch3 establishes brain vascular integrity by regulating pericyte number.
Notch3 activity gates neural stem cell activation in the adult pallium.
Title: Notch3 signaling gates cell cycle entry and limits neural stem cell amplification in the adult pallium.
knockdown of notch3 function in notch1a mutants leads to the loss of rhombomere boundary cells and causes neuronal hyperplasia
Title: Temporal Notch activation through Notch1a and Notch3 is required for maintaining zebrafish rhombomere boundaries.
Cellular correlates of Notch-delta gene expression in the regenerating zebrafish retina.
Title: Cellular correlates of proneural and Notch-delta gene expression in the regenerating zebrafish retina.

Submit: New GeneRIF Correction

General gene information

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Markers

aa605958 (e-PCR)
- UniSTS:186903

not5 (e-PCR)
- UniSTS:187004

fa14b08.s1 (e-PCR)
- UniSTS:188811

notch3 (e-PCR), detects polymorphism
- UniSTS:205556

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables Notch binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Notch signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within arterial endothelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel diameter maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in developmental growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dorsal aorta development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dorsal aorta development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within liver development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within maintenance of blood-brain barrier	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neurogenesis	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within negative regulation of neurogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neural plate development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuronal stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within oligodendrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peripheral nervous system neuron axonogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within pronephros development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of developmental process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of receptor-mediated endocytosis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of vascular permeability	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within rhombomere boundary formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within sclerotome development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within sclerotome development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somatic stem cell population maintenance	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within symmetric cell division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ventral spinal cord interneuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neurogenic locus notch homolog protein 3

Names: notch 3; notch homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131549.2 → NP_571624.2 neurogenic locus notch homolog protein 3 precursor

See identical proteins and their annotated locations for NP_571624.2

Status: PROVISIONAL

Source sequence(s)

AF152001

UniProtKB/TrEMBL

Q800E4

Related

ENSDARP00000068420.4, ENSDART00000073930.7

Conserved Domains (11) summary

smart00818
Location:2232 → 2325

Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth

COG0666
Location:1784 → 1896

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00054
Location:824 → 860

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00204
Location:1869 → 1995

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam00066
Location:1429 → 1462

Notch; LNR domain

pfam06816
Location:1508 → 1559

NOD; NOTCH protein

pfam07684
Location:1577 → 1634

NODP; NOTCH protein

pfam11936
Location:2384 → 2445

DUF3454; Domain of unknown function (DUF3454)

pfam12796
Location:1913 → 2005

Ank_2; Ankyrin repeats (3 copies)

pfam13857
Location:1861 → 1916

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:1908 → 1939

ANK; ANK repeat [structural motif]