U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

gata6 GATA binding protein 6 [ Danio rerio (zebrafish) ]

Gene ID: 58076, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
gata6provided by ZNC
Official Full Name
GATA binding protein 6provided by ZNC
Primary source
ZFIN:ZDB-GENE-000622-1
See related
Ensembl:ENSDARG00000103589 AllianceGenome:ZFIN:ZDB-GENE-000622-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb603; GATA-5
Summary
Enables DNA binding activity. Acts upstream of or within several processes, including cardioblast migration to the midline involved in heart field formation; liver development; and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including blastoderm; cardiovascular system; digestive system; mesoderm; and yolk syncytial layer. Human ortholog(s) of this gene implicated in adenocarcinoma (multiple); congenital heart disease (multiple); and pancreatic hypoplasia-diabetes-congenital heart disease syndrome. Orthologous to human GATA6 (GATA binding protein 6). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See gata6 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (4207160..4217877)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (4366055..4376928)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene MIB E3 ubiquitin protein ligase 1 Neighboring gene microRNA 133a-1 Neighboring gene microRNA 1-2 Neighboring gene uncharacterized LOC137487664 Neighboring gene Cdk5 and Abl enzyme substrate 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Functional characterization of GATA6 genetic variants associated with mild congenital heart defects. Wu H, et al. Biochem Biophys Res Commun, 2023 Jan 22. PMID 36525927
  2. Alleviation of seipinopathy-related ER stress by triglyceride storage. Hölttä-Vuori M, et al. Hum Mol Genet, 2013 Mar 15. PMID 23250914
  3. Modification of cardiac transcription factor Gata6 by SUMO. Chen H, et al. Biochimie, 2020 Mar. PMID 32017966
  4. Zebrafish as a platform to evaluate the potential of lipidic nanoemulsions for gene therapy in cancer. Cascallar M, et al. Front Pharmacol, 2022. PMID 36386231, Free PMC Article
  5. Functional characterization of CNOT3 variants identified in familial adenomatous polyposis adenomas. Delacruz RGC, et al. Oncotarget, 2019 Jun 11. PMID 31231471, Free PMC Article

See all (128) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional characterization of GATA6 genetic variants associated with mild congenital heart defects.
    Title: Functional characterization of GATA6 genetic variants associated with mild congenital heart defects.
  2. these data suggest an essential role for Pak1 as an Erk activator, and Gata6 as an Erk target, during neural crest development.
    Title: A Pak1/Erk signaling module acts through Gata6 to regulate cardiovascular development in zebrafish.
  3. specification of cardiac fate downstream of gata5/6 involves activation of the tmem88a gene to constrain WNT signaling and expand the number of cardiac progenitors.
    Title: Tmem88a mediates GATA-dependent specification of cardiomyocyte progenitors by restricting WNT signaling.
  4. Results suggest that GATA4 and -6 play a key role in the regulation of ventricular myosin heavy chain gene expression in the ventricle.
    Title: Isolation of a ventricle-specific promoter for the zebrafish ventricular myosin heavy chain (vmhc) gene and its regulation by GATA factors during embryonic heart development.
  5. in zebrafish the gata6 genes are redundant for specification of cardiomyocytes.
    Title: Gata5 and Gata6 are functionally redundant in zebrafish for specification of cardiomyocytes.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cardioblast migration to the midline involved in heart field formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within digestive tract development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epithelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within liver development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within myeloid cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
transcription factor GATA-6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001326364.1 → NP_001313293.1  transcription factor GATA-6

    Status: VALIDATED

    Source sequence(s)
    BX842700
    UniProtKB/TrEMBL
    A0A8N7XJJ1, Q6NW63, Q6TKR4
    Related
    ENSDARP00000136299.1, ENSDART00000157903.2
    Conserved Domains (3) summary
    smart00401
    Location:346 → 395
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:350 → 401
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    pfam05349
    Location:112 → 285
    GATA-N; GATA-type transcription activator, N-terminal

  2. NM_131557.2 → NP_571632.2  transcription factor GATA-6

    Status: VALIDATED

    Source sequence(s)
    BX842700
    UniProtKB/TrEMBL
    A0A8N7XJJ1, Q6NW63, Q6TKR4
    Related
    ENSDARP00000137653.1, ENSDART00000166476.2
    Conserved Domains (3) summary
    smart00401
    Location:346 → 395
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:350 → 401
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    pfam05349
    Location:112 → 285
    GATA-N; GATA-type transcription activator, N-terminal

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    4207160..4217877
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017358958.3 → XP_017214447.1  transcription factor GATA-6 isoform X2

    UniProtKB/TrEMBL
    A0A8M6Z1Y8
    Related
    ENSDARP00000129963.1, ENSDART00000167906.2

  2. XM_017358955.2 → XP_017214444.1  transcription factor GATA-6 isoform X1

    UniProtKB/TrEMBL
    A0A8N7XJJ1, Q6NW63, Q6TKR4
    Conserved Domains (3) summary
    smart00401
    Location:346 → 395
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:350 → 401
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    pfam05349
    Location:112 → 285
    GATA-N; GATA-type transcription activator, N-terminal
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.