fth1a ferritin, heavy polypeptide 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fth1aprovided by ZNC
Official Full Name: ferritin, heavy polypeptide 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-000831-2
See related: Ensembl:ENSDARG00000015551 AllianceGenome:ZFIN:ZDB-GENE-000831-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fth1; fb06g09; zeh1145; hm:zeh1145; wu:fb06g09; wu:fq18c10
Summary: Predicted to enable ferric iron binding activity and ferrous iron binding activity. Predicted to be involved in intracellular sequestering of iron ion. Predicted to act upstream of or within cellular iron ion homeostasis and iron ion transport. Predicted to be active in cytoplasm. Is expressed in blood; eye; liver; ovary; and testis. Human ortholog(s) of this gene implicated in hemochromatosis type 5. Orthologous to several human genes including FTH1 (ferritin heavy chain 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (12927944..12936708)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (12675210..12683988)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

fl03a09.x1 (e-PCR)
- UniSTS:201863

fb06g09.x1 (e-PCR)
- UniSTS:202720

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ferric iron binding	IBA Inferred from Biological aspect of Ancestor more info
enables ferric iron binding	IEA Inferred from Electronic Annotation more info
enables ferrous iron binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within intracellular iron ion homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within iron ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ferritin, heavy polypeptide 1a

Names: ferritin, heavy polypeptide 1

NP_571660.1

EC 1.16.3.1

XP_017212392.1

EC 1.16.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131585.1 → NP_571660.1 ferritin, heavy polypeptide 1a

See identical proteins and their annotated locations for NP_571660.1

Status: PROVISIONAL

Source sequence(s)

AF295373

UniProtKB/TrEMBL

A0A2R8QQC1, F6NRQ8, Q9DDT0

Related

ENSDARP00000026092.5, ENSDART00000027329.8

Conserved Domains (2) summary

cd01056
Location:11 → 170

Euk_Ferritin; eukaryotic ferritins

pfam00210
Location:14 → 155

Ferritin; Ferritin-like domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

12927944..12936708

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017356903.3 → XP_017212392.1 ferritin, heavy polypeptide 1a isoform X1

UniProtKB/TrEMBL

A0A2R8QQC1, F6NRQ8, Q9DDT0

Conserved Domains (2) summary

cd01056
Location:11 → 170

Euk_Ferritin; eukaryotic ferritins

pfam00210
Location:14 → 155

Ferritin; Ferritin-like domain