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hsf1 heat shock transcription factor 1 [ Danio rerio (zebrafish) ]

Gene ID: 58123, updated on 28-Oct-2024

Summary

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Official Symbol
hsf1provided by ZNC
Official Full Name
heat shock transcription factor 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-000616-16
See related
Ensembl:ENSDARG00000008818 AllianceGenome:ZFIN:ZDB-GENE-000616-16
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
HSF; HSF1c; hsf1a; hsf1b
Summary
Enables sequence-specific DNA binding activity. Acts upstream of or within lens development in camera-type eye and response to heat. Predicted to be active in nucleus. Is expressed in brain; head; and otic vesicle. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human HSF1 (heat shock transcription factor 1). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
human mouse all
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Genomic context

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See hsf1 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (3056417..3084637)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (3115507..3143739)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene HGH1 homolog (S. cerevisiae) Neighboring gene BOP1 ribosomal biogenesis factor Neighboring gene scleraxis bHLH transcription factor a Neighboring gene si:ch211-80h18.1 Neighboring gene starmaker

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Cloning of zebrafish (Danio rerio) heat shock factor 2 (HSF2) and similar patterns of HSF2 and HSF1 mRNA expression in brain tissues. Yeh FL, et al. Biochimie, 2006 Dec. PMID 16938384
  2. zHSF1 modulates zper2 expression in zebrafish embryos. Mennetrier L, et al. Chronobiol Int, 2018 Jul. PMID 29509048
  3. HSF1 is essential for the resistance of zebrafish eye and brain tissues to hypoxia/reperfusion injury. Tucker NR, et al. PLoS One, 2011. PMID 21814572, Free PMC Article
  4. Zebrafish HSF4: a novel protein that shares features of both HSF1 and HSF4 of mammals. Swan CL, et al. Cell Stress Chaperones, 2012 Sep. PMID 22528049, Free PMC Article
  5. HSP70, the earliest-induced gene in the zebrafish retina during optic nerve regeneration: its role in cell survival. Nagashima M, et al. Neurochem Int, 2011 Jul. PMID 21338645

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Specific Activation of Yamanaka Factors via HSF1 Signaling in the Early Stage of Zebrafish Optic Nerve Regeneration.
    Title: Specific Activation of Yamanaka Factors via HSF1 Signaling in the Early Stage of Zebrafish Optic Nerve Regeneration.
  2. that zHsf1 plays a positive role in HS-driven expression of zper2 in the dark but seems to act as an attenuator in the presence light
    Title: zHSF1 modulates zper2 expression in zebrafish embryos.
  3. The transcriptional up-regulation of unc45b, hsp90aa1.1 and smyd1b is specific to zebrafish mutants with myosin folding defects, and is not triggered in other zebrafish myopathy models
    Title: Loss of function of myosin chaperones triggers Hsf1-mediated transcriptional response in skeletal muscle cells.
  4. data suggest that HSF1 is involved in regulating constitutive lens specific expression of hsp70 in the embryonic zebrafish
    Title: Heat shock factor 1 is required for constitutive Hsp70 expression and normal lens development in embryonic zebrafish.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lens development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to heat IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
heat shock factor protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313736.1 → NP_001300665.1  heat shock factor protein 1

    Status: VALIDATED

    Source sequence(s)
    BX255894, CT574549, EH551245, EH572379
    UniProtKB/TrEMBL
    A0A8M1P7Q5, A4IG27, Q1LXV0
    Related
    ENSDARP00000076789.6, ENSDART00000082353.8
    Conserved Domains (3) summary
    smart00415
    Location:17 → 121
    HSF; heat shock factor
    pfam06546
    Location:244 → 497
    Vert_HS_TF; Vertebrate heat shock transcription factor
    cl23789
    Location:75 → 185
    PLN02481; Omega-hydroxypalmitate O-feruloyl transferase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    3056417..3084637
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009293954.4 → XP_009292229.1  heat shock factor protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M3B392, F6P697
    Related
    ENSDARP00000121268.2, ENSDART00000141324.4
    Conserved Domains (3) summary
    smart00415
    Location:17 → 121
    HSF; heat shock factor
    pfam06546
    Location:244 → 523
    Vert_HS_TF; Vertebrate heat shock transcription factor
    cl23789
    Location:75 → 185
    PLN02481; Omega-hydroxypalmitate O-feruloyl transferase

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_131600.1: Suppressed sequence

    Description
    NM_131600.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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