Wrap73 WD repeat containing, antisense to Trp73 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wrap73provided by MGI
Official Full Name: WD repeat containing, antisense to Trp73provided by MGI
Primary source: MGI:MGI:1891749
See related: Ensembl:ENSMUSG00000029029 AllianceGenome:MGI:1891749
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dd57; Wdr8; 2610044M17Rik; 5330425N03Rik
Summary: Predicted to be involved in mitotic nuclear division; positive regulation of non-motile cilium assembly; and protein localization to mitotic spindle pole body. Predicted to act upstream of or within cell projection organization. Predicted to be located in centrosome and ciliary basal body. Predicted to be part of MWP complex. Predicted to be active in microtubule organizing center and mitotic spindle. Is expressed in cerebral cortex and cerebral cortex mantle layer. Orthologous to human WRAP73 (WD repeat containing, antisense to TP73). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 22.1), adrenal adult (RPKM 18.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 83.86 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (154226811..154241278)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (154142354..154156821)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-motile cilium assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of MWP complex	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: WD repeat-containing protein WRAP73

Names: WD repeat domain 8; WD repeat-containing protein 8; WD repeat-containing protein antisense to TP73

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021499.2 → NP_067474.2 WD repeat-containing protein WRAP73

See identical proteins and their annotated locations for NP_067474.2

Status: VALIDATED

Source sequence(s)

AB034911, AK051688, BY063723

Consensus CDS

CCDS19010.1

UniProtKB/Swiss-Prot

Q8BQ21, Q9JM98

UniProtKB/TrEMBL

Q3T993

Related

ENSMUSP00000030895.6, ENSMUST00000030895.12

Conserved Domains (3) summary

COG2319
Location:13 → 413

WD40; WD40 repeat [General function prediction only]

sd00039
Location:14 → 47

7WD40; WD40 repeat [structural motif]

cl02567
Location:89 → 401

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

154226811..154241278

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036164284.1 → XP_036020177.1 WD repeat-containing protein WRAP73 isoform X1

Conserved Domains (2) summary

sd00039
Location:40 → 75

7WD40; WD40 repeat [structural motif]

cl29593
Location:36 → 249

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...