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Milr1 mast cell immunoglobulin-like receptor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 59105, updated on 10-Jul-2024

Summary

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Official Symbol
Milr1provided by RGD
Official Full Name
mast cell immunoglobulin-like receptor 1provided by RGD
Primary source
RGD:620488
See related
EnsemblRapid:ENSRNOG00000042524 AllianceGenome:RGD:620488
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mca32
Summary
Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in several processes, including cell-cell adhesion via plasma-membrane adhesion molecules; mast cell degranulation; and negative regulation of mast cell activation. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Orthologous to human MILR1 (mast cell immunoglobulin like receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 38.5), Spleen (RPKM 28.8) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Milr1 in Genome Data Viewer
Location:
10q32.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (92184002..92205001)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (91684288..91705284)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (94944243..94961795)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene transfer RNA proline (anticodon AGG) 83 Neighboring gene testis expressed 2 Neighboring gene platelet and endothelial cell adhesion molecule 1 Neighboring gene DNA polymerase gamma 2, accessory subunit Neighboring gene microRNA 3064 Neighboring gene DEAD-box helicase 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and characterization of a novel surface antigen gene induced in mast cells activated through the high affinity IgE receptor. Pirozzi G, et al. J Immunol, 1995 Dec 15. PMID 7499870
  2. An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions. Hitomi K, et al. Nat Immunol, 2010 Jul. PMID 20526344
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in mast cell degranulation ISO
Inferred from Sequence Orthology
more info
  
involved_in mast cell degranulation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of mast cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of mast cell activation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
allergin-1
Names
MCA-32
allergy inhibitory receptor 1
mast cell Ag-32
mast cell antigen 32
surface protein MCA-32

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410245.1 → NP_001397174.1  allergin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

  2. NM_021585.1 → NP_067596.1  allergin-1 isoform 1

    See identical proteins and their annotated locations for NP_067596.1

    Status: VALIDATED

    Source sequence(s)
    U39546
    UniProtKB/TrEMBL
    A0A0G2K456, A6HK54
    Related
    ENSRNOP00000072914.2, ENSRNOT00000078968.3
    Conserved Domains (2) summary
    smart00410
    Location:82 → 151
    IG_like; Immunoglobulin like
    pfam13895
    Location:74 → 158
    Ig_2; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    92184002..92205001
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086732.2 → XP_038942660.1  allergin-1 isoform X8

    Conserved Domains (1) summary
    smart00409
    Location:3 → 72
    IG; Immunoglobulin

  2. XM_039086730.2 → XP_038942658.1  allergin-1 isoform X8

    Conserved Domains (1) summary
    smart00409
    Location:3 → 72
    IG; Immunoglobulin

  3. XM_039086729.2 → XP_038942657.1  allergin-1 isoform X8

    Conserved Domains (1) summary
    smart00409
    Location:3 → 72
    IG; Immunoglobulin

  4. XM_039086731.2 → XP_038942659.1  allergin-1 isoform X8

    Conserved Domains (1) summary
    smart00409
    Location:3 → 72
    IG; Immunoglobulin

  5. XM_017597497.3 → XP_017452986.1  allergin-1 isoform X3

    UniProtKB/TrEMBL
    A6HK55

  6. XM_039086726.2 → XP_038942654.1  allergin-1 isoform X4

    UniProtKB/TrEMBL
    A6HK55
    Conserved Domains (1) summary
    pfam13895
    Location:74 → 155
    Ig_2; Immunoglobulin domain

  7. XM_008768388.4 → XP_008766610.1  allergin-1 isoform X6

    UniProtKB/TrEMBL
    A6HK55
    Conserved Domains (2) summary
    smart00410
    Location:82 → 151
    IG_like; Immunoglobulin like
    pfam13895
    Location:74 → 158
    Ig_2; Immunoglobulin domain

  8. XM_039086725.2 → XP_038942653.1  allergin-1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K456, A6HK54
    Conserved Domains (1) summary
    pfam13895
    Location:74 → 155
    Ig_2; Immunoglobulin domain

  9. XM_008768389.4 → XP_008766611.1  allergin-1 isoform X7

    UniProtKB/TrEMBL
    A6HK55
    Conserved Domains (2) summary
    smart00410
    Location:82 → 151
    IG_like; Immunoglobulin like
    pfam13895
    Location:74 → 158
    Ig_2; Immunoglobulin domain

  10. XM_039086724.2 → XP_038942652.1  allergin-1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K456, A6HK54
    Conserved Domains (1) summary
    pfam13895
    Location:74 → 155
    Ig_2; Immunoglobulin domain

  11. XM_039086733.2 → XP_038942661.1  allergin-1 isoform X9

    UniProtKB/TrEMBL
    A0A0G2K456, A6HK54
    Conserved Domains (1) summary
    pfam13895
    Location:74 → 155
    Ig_2; Immunoglobulin domain

  12. XM_039086727.2 → XP_038942655.1  allergin-1 isoform X5

    UniProtKB/Swiss-Prot
    Q62875
    Conserved Domains (1) summary
    smart00409
    Location:30 → 99
    IG; Immunoglobulin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62875.2 GenPept UniProtKB/Swiss-Prot:Q62875

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