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RNH1 ribonuclease/angiogenin inhibitor 1 [ Homo sapiens (human) ]

Gene ID: 6050, updated on 3-Nov-2024

Summary

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Official Symbol
RNH1provided by HGNC
Official Full Name
ribonuclease/angiogenin inhibitor 1provided by HGNC
Primary source
HGNC:HGNC:10074
See related
Ensembl:ENSG00000023191 MIM:173320; AllianceGenome:HGNC:10074
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAI; RNH; IIAE12
Summary
Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010]
Expression
Ubiquitous expression in skin (RPKM 36.6), lung (RPKM 36.0) and 25 other tissues See more
Orthologs
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Genomic context

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See RNH1 in Genome Data Viewer
Location:
11p15.5
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (494515..507242, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (540227..553016, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (494515..507242, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376506 Neighboring gene anoctamin 9 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3005 Neighboring gene Sharpr-MPRA regulatory region 223 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:442612-443409 Neighboring gene RNA, 7SL, cytoplasmic 838, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4275 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3006 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3007 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:449779-450465 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3009 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3010 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:454927-455648 Neighboring gene phosphatidylserine synthase 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:460662-460845 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:467161-467660 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:471334-471857 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:471858-472380 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:476893-477888 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:484337-484858 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:487868-488008 Neighboring gene MPRA-validated peak1145 silencer Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_21531 Neighboring gene leucine rich repeat containing 56 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:528505-529042 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:533792-534649 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:534650-535506 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:535528-536235 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:540668-541490 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:543860-544362 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:544865-545366 Neighboring gene HRas proto-oncogene, GTPase Neighboring gene H3K4me1 hESC enhancers GRCh37_chr11:548147-548965 and GRCh37_chr11:548966-549783 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:556675-557511 Neighboring gene LMNTD2 antisense RNA 1 Neighboring gene lamin tail domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Mapping of the human ribonuclease inhibitor gene (RNH) to chromosome 11p15 by in situ hybridization. Zneimer SM, et al. Genomics, 1990 Sep. PMID 2081593
  2. Down-regulating ribonuclease inhibitor enhances metastasis of bladder cancer cells through regulating epithelial-mesenchymal transition and ILK signaling pathway. Xiong D, et al. Exp Mol Pathol, 2014 Jun. PMID 24768914
  3. RNH1 regulation of reactive oxygen species contributes to histone deacetylase inhibitor resistance in gastric cancer cells. Zhu Y, et al. Oncogene, 2014 Mar 20. PMID 23584480
  4. The ribonuclease/angiogenin inhibitor is also present in mitochondria and nuclei. Furia A, et al. FEBS Lett, 2011 Feb 18. PMID 21276451
  5. Knockdown of ribonuclease inhibitor expression with siRNA in non-invasive bladder cancer cell line BIU-87 promotes growth and metastasis potentials. Chen J, et al. Mol Cell Biochem, 2011 Mar. PMID 21125316

See all (170) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. New link between RNH1 and E2F1: regulates the development of lung adenocarcinoma.
    Title: New link between RNH1 and E2F1: regulates the development of lung adenocarcinoma.
  2. Biallelic variants in ribonuclease inhibitor (RNH1), an inflammasome modulator, are associated with a distinctive subtype of acute, necrotizing encephalopathy.
    Title: Biallelic variants in ribonuclease inhibitor (RNH1), an inflammasome modulator, are associated with a distinctive subtype of acute, necrotizing encephalopathy.
  3. Ribonuclease inhibitor 1 (RNH1) deficiency cause congenital cataracts and global developmental delay with infection-induced psychomotor regression and anemia.
    Title: Ribonuclease inhibitor 1 (RNH1) deficiency cause congenital cataracts and global developmental delay with infection-induced psychomotor regression and anemia.
  4. Functional status analysis of RNH1 in bladder cancer for predicting immunotherapy response.
    Title: Functional status analysis of RNH1 in bladder cancer for predicting immunotherapy response.
  5. LRR-protein RNH1 dampens the inflammasome activation and is associated with COVID-19 severity.
    Title: LRR-protein RNH1 dampens the inflammasome activation and is associated with COVID-19 severity.
  6. Angiogenin (ANG)-Ribonuclease Inhibitor (RNH1) System in Protein Synthesis and Disease.
    Title: Angiogenin (ANG)-Ribonuclease Inhibitor (RNH1) System in Protein Synthesis and Disease.
  7. This study first time revealed in vivo role of RNH1. This study report that RNH1 is important for embryonic development and erythropoiesis. RNH1 binds to ribosomes and regulates erythropoiesis by controlling translation of the erythroid transcription factor GATA1.
    Title: Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation.
  8. RNH1 might represent the first direct regulator of IRE1 RNase activity
    Title: Regulation of IRE1 RNase activity by the Ribonuclease inhibitor 1 (RNH1).
  9. Results show that a low expression of RNH1 in metastasis of bladder cancer and suggest that it might regulate the function of ILK through mutual binding.
    Title: Interplay between intergrin-linked kinase and ribonuclease inhibitor affects growth and metastasis of bladder cancer through signaling ILK pathways.
  10. Data suggest that ribonuclease inhibitor (RNH1) protects HeLa cells from ribonuclease 1 (RNase 1).
    Title: Knockout of the Ribonuclease Inhibitor Gene Leaves Human Cells Vulnerable to Secretory Ribonucleases.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Encephalitis, acute, infection-induced, susceptibility to, 12
MedGen: C5882673 OMIM: 620461 GeneReviews: Not available
not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of ribonuclease/angiogenin inhibitor 1 (RNH1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with RNH1 PubMed
nucleocapsid gag HIV-1 NC is identified to have a physical interaction with ribonuclease/angiogenin inhibitor 1 (RNH1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human ribonuclease/angiogenin inhibitor 1 (RNH1) at amino acid residues 445-446 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC4569, MGC18200, MGC54054

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribonuclease inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonuclease inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of angiogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of angiogenin-PRI complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of angiogenin-PRI complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in extracellular exosome HDA PubMed 
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ribonuclease inhibitor
Names
placental RNase inhibitor
placental ribonuclease inhibitor
testicular tissue protein Li 164

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002939.4 → NP_002930.2  ribonuclease inhibitor

    See identical proteins and their annotated locations for NP_002930.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All eight variants of this gene encode the same protein.
    Source sequence(s)
    BC047730
    Consensus CDS
    CCDS7697.1
    UniProtKB/Swiss-Prot
    P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
    UniProtKB/TrEMBL
    A0A140VJT8
    Related
    ENSP00000380739.2, ENST00000397615.6
    Conserved Domains (3) summary
    smart00368
    Location:397 → 424
    LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
    cd00116
    Location:6 → 325
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:6 → 29
    LRR_RI; leucine-rich repeat [structural motif]

  2. NM_203383.2 → NP_976317.1  ribonuclease inhibitor

    See identical proteins and their annotated locations for NP_976317.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. All eight variants of this gene encode the same protein.
    Source sequence(s)
    BC011186, BG752774
    Consensus CDS
    CCDS7697.1
    UniProtKB/Swiss-Prot
    P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
    UniProtKB/TrEMBL
    A0A140VJT8
    Conserved Domains (3) summary
    smart00368
    Location:397 → 424
    LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
    cd00116
    Location:6 → 325
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:6 → 29
    LRR_RI; leucine-rich repeat [structural motif]

  3. NM_203384.2 → NP_976318.1  ribonuclease inhibitor

    See identical proteins and their annotated locations for NP_976318.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon and uses a different splice site in the 5' UTR, compared to variant 1. All eight variants of this gene encode the same protein.
    Source sequence(s)
    BC003506, BC011186, BM019570
    Consensus CDS
    CCDS7697.1
    UniProtKB/Swiss-Prot
    P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
    UniProtKB/TrEMBL
    A0A140VJT8
    Related
    ENSP00000416589.2, ENST00000438658.6
    Conserved Domains (3) summary
    smart00368
    Location:397 → 424
    LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
    cd00116
    Location:6 → 325
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:6 → 29
    LRR_RI; leucine-rich repeat [structural motif]

  4. NM_203385.2 → NP_976319.1  ribonuclease inhibitor

    See identical proteins and their annotated locations for NP_976319.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon in the 5' UTR, compared to variant 1. All eight variants of this gene encode the same protein.
    Source sequence(s)
    BC011186, BM019570, BQ954409
    Consensus CDS
    CCDS7697.1
    UniProtKB/Swiss-Prot
    P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
    UniProtKB/TrEMBL
    A0A140VJT8
    Related
    ENSP00000380738.1, ENST00000397614.5
    Conserved Domains (3) summary
    smart00368
    Location:397 → 424
    LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
    cd00116
    Location:6 → 325
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:6 → 29
    LRR_RI; leucine-rich repeat [structural motif]

  5. NM_203386.3 → NP_976320.1  ribonuclease inhibitor

    See identical proteins and their annotated locations for NP_976320.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains a different exon and uses a different splice site in its 5' UTR, compared to variant 1. All eight variants of this gene encode the same protein.
    Source sequence(s)
    AC137894, BC011186, BM465975
    Consensus CDS
    CCDS7697.1
    UniProtKB/Swiss-Prot
    P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
    UniProtKB/TrEMBL
    A0A140VJT8
    Related
    ENSP00000435594.1, ENST00000533410.5
    Conserved Domains (3) summary
    smart00368
    Location:397 → 424
    LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
    cd00116
    Location:6 → 325
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:6 → 29
    LRR_RI; leucine-rich repeat [structural motif]

  6. NM_203387.3 → NP_976321.1  ribonuclease inhibitor

    See identical proteins and their annotated locations for NP_976321.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains a different exon in its 5' UTR, compared to variant 1. All eight variants of this gene encode the same protein.
    Source sequence(s)
    AC137894, BC011186, DC296330
    Consensus CDS
    CCDS7697.1
    UniProtKB/Swiss-Prot
    P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
    UniProtKB/TrEMBL
    A0A140VJT8
    Related
    ENSP00000346402.2, ENST00000354420.7
    Conserved Domains (3) summary
    smart00368
    Location:397 → 424
    LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
    cd00116
    Location:6 → 325
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:6 → 29
    LRR_RI; leucine-rich repeat [structural motif]

  7. NM_203388.3 → NP_976322.1  ribonuclease inhibitor

    See identical proteins and their annotated locations for NP_976322.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) has multiple differences in its 5' UTR, compared to variant 1. All eight variants of this gene encode the same protein.
    Source sequence(s)
    AC137894, BC011500
    Consensus CDS
    CCDS7697.1
    UniProtKB/Swiss-Prot
    P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
    UniProtKB/TrEMBL
    A0A140VJT8
    Related
    ENSP00000380729.3, ENST00000397604.7
    Conserved Domains (3) summary
    smart00368
    Location:397 → 424
    LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
    cd00116
    Location:6 → 325
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:6 → 29
    LRR_RI; leucine-rich repeat [structural motif]

  8. NM_203389.3 → NP_976323.1  ribonuclease inhibitor

    See identical proteins and their annotated locations for NP_976323.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) has multiple differences in its 5' UTR, compared to variant 1. All eight variants of this gene encode the same protein.
    Source sequence(s)
    AC137894, BC014629
    Consensus CDS
    CCDS7697.1
    UniProtKB/Swiss-Prot
    P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
    UniProtKB/TrEMBL
    A0A140VJT8
    Related
    ENSP00000348515.5, ENST00000356187.9
    Conserved Domains (3) summary
    smart00368
    Location:397 → 424
    LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
    cd00116
    Location:6 → 325
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:6 → 29
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    494515..507242 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520260.3 → XP_011518562.1  ribonuclease inhibitor isoform X1

    See identical proteins and their annotated locations for XP_011518562.1

    UniProtKB/Swiss-Prot
    P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
    UniProtKB/TrEMBL
    A0A140VJT8
    Conserved Domains (3) summary
    smart00368
    Location:397 → 424
    LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
    cd00116
    Location:6 → 325
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:6 → 29
    LRR_RI; leucine-rich repeat [structural motif]

  2. XM_011520255.2 → XP_011518557.1  ribonuclease inhibitor isoform X1

    See identical proteins and their annotated locations for XP_011518557.1

    UniProtKB/Swiss-Prot
    P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
    UniProtKB/TrEMBL
    A0A140VJT8
    Conserved Domains (3) summary
    smart00368
    Location:397 → 424
    LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
    cd00116
    Location:6 → 325
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:6 → 29
    LRR_RI; leucine-rich repeat [structural motif]

  3. XM_011520261.3 → XP_011518563.1  ribonuclease inhibitor isoform X1

    See identical proteins and their annotated locations for XP_011518563.1

    UniProtKB/Swiss-Prot
    P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
    UniProtKB/TrEMBL
    A0A140VJT8
    Conserved Domains (3) summary
    smart00368
    Location:397 → 424
    LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
    cd00116
    Location:6 → 325
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:6 → 29
    LRR_RI; leucine-rich repeat [structural motif]

  4. XM_017018106.2 → XP_016873595.1  ribonuclease inhibitor isoform X1

    UniProtKB/Swiss-Prot
    P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
    UniProtKB/TrEMBL
    A0A140VJT8
    Conserved Domains (3) summary
    smart00368
    Location:397 → 424
    LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
    cd00116
    Location:6 → 325
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:6 → 29
    LRR_RI; leucine-rich repeat [structural motif]

  5. XM_011520263.2 → XP_011518565.1  ribonuclease inhibitor isoform X1

    See identical proteins and their annotated locations for XP_011518565.1

    UniProtKB/Swiss-Prot
    P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
    UniProtKB/TrEMBL
    A0A140VJT8
    Conserved Domains (3) summary
    smart00368
    Location:397 → 424
    LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
    cd00116
    Location:6 → 325
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:6 → 29
    LRR_RI; leucine-rich repeat [structural motif]

  6. XM_011520259.4 → XP_011518561.1  ribonuclease inhibitor isoform X1

    See identical proteins and their annotated locations for XP_011518561.1

    UniProtKB/Swiss-Prot
    P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
    UniProtKB/TrEMBL
    A0A140VJT8
    Related
    ENSP00000433999.1, ENST00000534797.5
    Conserved Domains (3) summary
    smart00368
    Location:397 → 424
    LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
    cd00116
    Location:6 → 325
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:6 → 29
    LRR_RI; leucine-rich repeat [structural motif]

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187586.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    24156..36883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328929.1 → XP_054184904.1  ribonuclease inhibitor isoform X1

    UniProtKB/Swiss-Prot
    P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
    UniProtKB/TrEMBL
    A0A140VJT8

  2. XM_054328928.1 → XP_054184903.1  ribonuclease inhibitor isoform X1

    UniProtKB/Swiss-Prot
    P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
    UniProtKB/TrEMBL
    A0A140VJT8

  3. XM_054328924.1 → XP_054184899.1  ribonuclease inhibitor isoform X1

    UniProtKB/Swiss-Prot
    P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
    UniProtKB/TrEMBL
    A0A140VJT8

  4. XM_054328923.1 → XP_054184898.1  ribonuclease inhibitor isoform X1

    UniProtKB/Swiss-Prot
    P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
    UniProtKB/TrEMBL
    A0A140VJT8

  5. XM_054328926.1 → XP_054184901.1  ribonuclease inhibitor isoform X1

    UniProtKB/Swiss-Prot
    P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
    UniProtKB/TrEMBL
    A0A140VJT8

  6. XM_054328925.1 → XP_054184900.1  ribonuclease inhibitor isoform X1

    UniProtKB/Swiss-Prot
    P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
    UniProtKB/TrEMBL
    A0A140VJT8

  7. XM_054328927.1 → XP_054184902.1  ribonuclease inhibitor isoform X1

    UniProtKB/Swiss-Prot
    P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
    UniProtKB/TrEMBL
    A0A140VJT8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    540227..553016 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369610.1 → XP_054225585.1  ribonuclease inhibitor isoform X1

  2. XM_054369606.1 → XP_054225581.1  ribonuclease inhibitor isoform X1

  3. XM_054369604.1 → XP_054225579.1  ribonuclease inhibitor isoform X1

  4. XM_054369607.1 → XP_054225582.1  ribonuclease inhibitor isoform X1

  5. XM_054369605.1 → XP_054225580.1  ribonuclease inhibitor isoform X1

  6. XM_054369609.1 → XP_054225584.1  ribonuclease inhibitor isoform X1

  7. XM_054369608.1 → XP_054225583.1  ribonuclease inhibitor isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P13489.2 GenPept UniProtKB/Swiss-Prot:P13489

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