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pax8 paired box 8 [ Danio rerio (zebrafish) ]

Gene ID: 60637, updated on 2-Nov-2024

Summary

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Official Symbol
pax8provided by ZNC
Official Full Name
paired box 8provided by ZNC
Primary source
ZFIN:ZDB-GENE-001030-3
See related
Ensembl:ENSDARG00000015879 AllianceGenome:ZFIN:ZDB-GENE-001030-3
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within anterior/posterior pattern specification involved in pronephros development; otic placode formation; and peripheral nervous system development. Predicted to be located in nucleus. Is expressed in several structures, including endocrine system; mesoderm; nervous system; neurogenic field; and pronephros. Human ortholog(s) of this gene implicated in congenital hypothyroidism and congenital nongoitrous hypothyroidism 2. Orthologous to human PAX8 (paired box 8). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See pax8 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (72407498..72416098, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (71634624..71643126, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene WW domain binding protein 1 Neighboring gene thioredoxin domain-containing protein 2-like Neighboring gene PH and SEC7 domain-containing protein 4 Neighboring gene zinc finger protein 154 Neighboring gene hydroxycarboxylic acid receptor 2-

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Formation of the spinal network in zebrafish determined by domain-specific pax genes. Ikenaga T, et al. J Comp Neurol, 2011 Jun 1. PMID 21452218, Free PMC Article
  2. Transgenic line with gal4 insertion useful to study morphogenesis of craniofacial perichondrium, vascular endothelium-associated cells, floor plate, and dorsal midline radial glia during zebrafish development. Nakayama S, et al. Dev Growth Differ, 2012 Feb. PMID 22348745, Free PMC Article
  3. Unraveling molecular targets of bisphenol A and S in the thyroid gland. Berto-Júnior C, et al. Environ Sci Pollut Res Int, 2018 Sep. PMID 30006815
  4. Vitamin D receptor deficiency impairs inner ear development in zebrafish. Kwon HJ. Biochem Biophys Res Commun, 2016 Sep 16. PMID 27526995
  5. Bisphenol A interferes with thyroid specific gene expression. Gentilcore D, et al. Toxicology, 2013 Feb 8. PMID 23238275

See all (104) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pax2a and Pax8 regulate cell differentiation during sensory placode formation
    Title: Graded levels of Pax2a and Pax8 regulate cell differentiation during sensory placode formation.
  2. pax8 works with related genes pax2a/pax2b to downregulate otic expression of foxi1, a necessary step for further otic development
    Title: Pax2/8 proteins coordinate sequential induction of otic and epibranchial placodes through differential regulation of foxi1, sox3 and fgf24.
  3. Pax2a and Pax8 are the main effectors downstream of Fgf signals in ear formation
    Title: Pax8 and Pax2a function synergistically in otic specification, downstream of the Foxi1 and Dlx3b transcription factors.
  4. pax8 is initially required for normal otic induction, and subsequently pax8, pax2a and pax2b act redundantly to maintain otic fate
    Title: Zebrafish pax8 is required for otic placode induction and plays a redundant role with Pax2 genes in the maintenance of the otic placode.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within anterior/posterior pattern specification involved in pronephros development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within otic placode formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within otic placode formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within peripheral nervous system development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory organ development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
paired box protein Pax-8
Names
paired box gene 8

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    72407498..72416098 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021476713.2 → XP_021332388.1  paired box protein Pax-8 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PZA2
    Conserved Domains (2) summary
    smart00351
    Location:2 → 115
    PAX; Paired Box domain
    pfam12403
    Location:326 → 420
    Pax2_C; Paired-box protein 2 C terminal

  2. XM_017356403.3 → XP_017211892.1  paired box protein Pax-8 isoform X3

    UniProtKB/TrEMBL
    A0A8M6Z787

  3. XM_001339857.9 → XP_001339893.5  paired box protein Pax-8 isoform X1

    UniProtKB/TrEMBL
    A0A8M1PSE2, F1Q9Q9
    Related
    ENSDARP00000033414.7, ENSDART00000029014.8
    Conserved Domains (2) summary
    smart00351
    Location:8 → 132
    PAX; Paired Box domain
    pfam12403
    Location:343 → 437
    Pax2_C; Paired-box protein 2 C terminal
Nucleotide Protein Strain
Heading Accession and Version

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