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pabpc1a poly(A) binding protein, cytoplasmic 1a [ Danio rerio (zebrafish) ]

Gene ID: 606498, updated on 2-Nov-2024

Summary

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Official Symbol
pabpc1aprovided by ZNC
Official Full Name
poly(A) binding protein, cytoplasmic 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3238
See related
Ensembl:ENSDARG00000017219 AllianceGenome:ZFIN:ZDB-GENE-030131-3238
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
pabpc1; PABP-1A; wu:fb16a02; wu:fi19b08; wu:fj12d09; wu:fj61f06; zgc:109879
Summary
Predicted to enable mRNA 3'-UTR binding activity; poly(A) binding activity; and poly(U) RNA binding activity. Acts upstream of or within heart development. Predicted to be located in cytoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasmic stress granule; cytosol; and nucleus. Is expressed in several structures, including blastodisc; digestive system; eye; pectoral fin bud; and ventral mesenchyme. Orthologous to several human genes including PABPC1 (poly(A) binding protein cytoplasmic 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See pabpc1a in Genome Data Viewer
Location:
chromosome: 16
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (54829283..54851248)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (55121197..55143081)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 7B Neighboring gene pleckstrin homology-like domain family B member 1 Neighboring gene nuclear receptor subfamily 0, group B, member 2a Neighboring gene keratinocyte differentiation factor 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Poly(A)-binding proteins are required for microRNA-mediated silencing and to promote target deadenylation in C. elegans. Flamand MN, et al. Nucleic Acids Res, 2016 Jul 8. PMID 27095199, Free PMC Article
  2. Zebrafish fin regeneration involves transient serotonin synthesis. König D, et al. Wound Repair Regen, 2019 Jul. PMID 31017740
  3. Translational inhibition by deadenylation-independent mechanisms is central to microRNA-mediated silencing in zebrafish. Mishima Y, et al. Proc Natl Acad Sci U S A, 2012 Jan 24. PMID 22232654, Free PMC Article
  4. Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA. Hosono Y, et al. Cell, 2017 Dec 14. PMID 29245011, Free PMC Article
  5. RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay. Yang Y, et al. Mol Cell, 2019 Sep 19. PMID 31399345

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(U) RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
polyadenylate-binding protein 1A
Names
poly A binding protein, cytoplasmic 1 a
poly(A)-binding protein 1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031676.1 → NP_001026846.1  polyadenylate-binding protein 1A

    See identical proteins and their annotated locations for NP_001026846.1

    Status: PROVISIONAL

    Source sequence(s)
    BC099992
    UniProtKB/TrEMBL
    Q499B6
    Related
    ENSDARP00000021064.7, ENSDART00000024729.9
    Conserved Domains (1) summary
    TIGR01628
    Location:11 → 614
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    54829283..54851248
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005169771.5 → XP_005169828.1  polyadenylate-binding protein 1A isoform X1

    UniProtKB/Swiss-Prot
    F1QB54, Q499B6, Q6P5M4
    Related
    ENSDARP00000124828.1, ENSDART00000148392.2
    Conserved Domains (1) summary
    TIGR01628
    Location:11 → 614
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F1QB54.1 GenPept UniProtKB/Swiss-Prot:F1QB54

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