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RPL17 ribosomal protein L17 [ Homo sapiens (human) ]

Gene ID: 6139, updated on 7-Apr-2024

Summary

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Official Symbol
RPL17provided by HGNC
Official Full Name
ribosomal protein L17provided by HGNC
Primary source
HGNC:HGNC:10307
See related
Ensembl:ENSG00000265681 MIM:603661; AllianceGenome:HGNC:10307
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L17; PD-1; uL22; RPL23
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL23 because the encoded protein shares amino acid identity with ribosomal protein L23 from Halobacterium marismortui; however, its official symbol is RPL17. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream C18orf32 (chromosome 18 open reading frame 32) gene. [provided by RefSeq, Dec 2010]
Expression
Ubiquitous expression in ovary (RPKM 688.1), bone marrow (RPKM 341.0) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
18q21.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (49488481..49492465, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (49686222..49690206, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (47014851..47018835, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene RPL17-C18orf32 readthrough Neighboring gene chromosome 18 open reading frame 32 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9449 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13309 Neighboring gene microRNA 1539 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:47018229-47018849 Neighboring gene small nucleolar RNA, C/D box 58C Neighboring gene small nucleolar RNA, C/D box 58A Neighboring gene small nucleolar RNA, C/D box 58B Neighboring gene signal recognition particle 72 pseudogene 1 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr18:47026295-47027190 Neighboring gene long intergenic non-protein coding RNA 2837 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:47042044-47042658

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A human gene related to the ribosomal protein L23 gene of Halobacterium marismortui. Mager DL, et al. Nucleic Acids Res, 1990 Sep 11. PMID 2402465, Free PMC Article
  2. Integrated profiling of phenotype and blood transcriptome for stress vulnerability and depression. Hori H, et al. J Psychiatr Res, 2018 Sep. PMID 30103068
  3. An ER translocon for multi-pass membrane protein biogenesis. McGilvray PT, et al. Elife, 2020 Aug 21. PMID 32820719, Free PMC Article
  4. TRAF4 Maintains Deubiquitination of Caveolin-1 to Drive Glioblastoma Stemness and Temozolomide Resistance. Li Y, et al. Cancer Res, 2022 Oct 4. PMID 35895752
  5. NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells. Katzenellenbogen RA, et al. J Virol, 2007 Apr. PMID 17267499, Free PMC Article

See all (181) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L17 (RPL17), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L17 (RPL17), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L17 (RPL17), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L17 (RPL17), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Rev rev HIV-1 Rev interacting protein, ribosomal protein L17 (RPL17), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
Tat tat Expression of HIV-1 Tat upregulates the abundance of ribosomal protein L17 (RPL17) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ18762, FLJ92089, MGC117162

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic large ribosomal subunit HDA PubMed 
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
large ribosomal subunit protein uL22
Names
60S ribosomal protein L17
60S ribosomal protein L23
gene encoding putative NFkB activating protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000985.5 → NP_000976.1  large ribosomal subunit protein uL22 isoform a

    See identical proteins and their annotated locations for NP_000976.1

    Status: REVIEWED

    Source sequence(s)
    AC100778
    Consensus CDS
    CCDS45865.1
    UniProtKB/Swiss-Prot
    B2R4H3, B4E3C2, B5ME31, J3QL51, P18621, Q3KQW2, Q6NZ54, Q7M4M5
    UniProtKB/TrEMBL
    J3KRX5
    Related
    ENSP00000463842.1, ENST00000579408.5
    Conserved Domains (1) summary
    PTZ00178
    Location:1 → 165
    PTZ00178; 60S ribosomal protein L17; Provisional

  2. NM_001035006.5 → NP_001030178.1  large ribosomal subunit protein uL22 isoform a

    See identical proteins and their annotated locations for NP_001030178.1

    Status: REVIEWED

    Source sequence(s)
    AC100778
    Consensus CDS
    CCDS45865.1
    UniProtKB/Swiss-Prot
    B2R4H3, B4E3C2, B5ME31, J3QL51, P18621, Q3KQW2, Q6NZ54, Q7M4M5
    UniProtKB/TrEMBL
    J3KRX5
    Related
    ENSP00000462385.1, ENST00000580261.6
    Conserved Domains (1) summary
    PTZ00178
    Location:1 → 165
    PTZ00178; 60S ribosomal protein L17; Provisional

  3. NM_001199340.2 → NP_001186269.1  large ribosomal subunit protein uL22 isoform a

    See identical proteins and their annotated locations for NP_001186269.1

    Status: REVIEWED

    Source sequence(s)
    AC100778
    Consensus CDS
    CCDS45865.1
    UniProtKB/Swiss-Prot
    B2R4H3, B4E3C2, B5ME31, J3QL51, P18621, Q3KQW2, Q6NZ54, Q7M4M5
    UniProtKB/TrEMBL
    J3KRX5
    Conserved Domains (1) summary
    PTZ00178
    Location:1 → 165
    PTZ00178; 60S ribosomal protein L17; Provisional

  4. NM_001199341.3 → NP_001186270.1  large ribosomal subunit protein uL22 isoform a

    See identical proteins and their annotated locations for NP_001186270.1

    Status: REVIEWED

    Source sequence(s)
    AC100778
    Consensus CDS
    CCDS45865.1
    UniProtKB/Swiss-Prot
    B2R4H3, B4E3C2, B5ME31, J3QL51, P18621, Q3KQW2, Q6NZ54, Q7M4M5
    UniProtKB/TrEMBL
    J3KRX5
    Related
    ENSP00000462023.1, ENST00000579248.5
    Conserved Domains (1) summary
    PTZ00178
    Location:1 → 165
    PTZ00178; 60S ribosomal protein L17; Provisional

  5. NM_001199342.3 → NP_001186271.1  large ribosomal subunit protein uL22 isoform a

    See identical proteins and their annotated locations for NP_001186271.1

    Status: REVIEWED

    Source sequence(s)
    AC100778
    Consensus CDS
    CCDS45865.1
    UniProtKB/Swiss-Prot
    B2R4H3, B4E3C2, B5ME31, J3QL51, P18621, Q3KQW2, Q6NZ54, Q7M4M5
    UniProtKB/TrEMBL
    J3KRX5
    Related
    ENSP00000480555.1, ENST00000618613.5
    Conserved Domains (1) summary
    PTZ00178
    Location:1 → 165
    PTZ00178; 60S ribosomal protein L17; Provisional

  6. NM_001199343.3 → NP_001186272.1  large ribosomal subunit protein uL22 isoform a

    See identical proteins and their annotated locations for NP_001186272.1

    Status: REVIEWED

    Source sequence(s)
    AC100778
    Consensus CDS
    CCDS45865.1
    UniProtKB/Swiss-Prot
    B2R4H3, B4E3C2, B5ME31, J3QL51, P18621, Q3KQW2, Q6NZ54, Q7M4M5
    UniProtKB/TrEMBL
    J3KRX5
    Related
    ENSP00000462203.1, ENST00000583637.5
    Conserved Domains (1) summary
    PTZ00178
    Location:1 → 165
    PTZ00178; 60S ribosomal protein L17; Provisional

  7. NM_001199344.3 → NP_001186273.1  large ribosomal subunit protein uL22 isoform a

    See identical proteins and their annotated locations for NP_001186273.1

    Status: REVIEWED

    Source sequence(s)
    AC100778
    Consensus CDS
    CCDS45865.1
    UniProtKB/Swiss-Prot
    B2R4H3, B4E3C2, B5ME31, J3QL51, P18621, Q3KQW2, Q6NZ54, Q7M4M5
    UniProtKB/TrEMBL
    J3KRX5
    Related
    ENSP00000463885.1, ENST00000578532.5
    Conserved Domains (1) summary
    PTZ00178
    Location:1 → 165
    PTZ00178; 60S ribosomal protein L17; Provisional

  8. NM_001199345.2 → NP_001186274.1  large ribosomal subunit protein uL22 isoform b

    See identical proteins and their annotated locations for NP_001186274.1

    Status: REVIEWED

    Source sequence(s)
    AC100778
    Consensus CDS
    CCDS56070.1
    UniProtKB/Swiss-Prot
    P18621
    Related
    ENSP00000462944.1, ENST00000581373.5
    Conserved Domains (1) summary
    PTZ00178
    Location:1 → 127
    PTZ00178; 60S ribosomal protein L17; Provisional

  9. NM_001369555.1 → NP_001356484.1  large ribosomal subunit protein uL22 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC100778
    UniProtKB/TrEMBL
    J3KRX5
    Conserved Domains (1) summary
    PTZ00178
    Location:1 → 170
    PTZ00178; 60S ribosomal protein L17; Provisional

  10. NM_001369556.1 → NP_001356485.1  large ribosomal subunit protein uL22 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC100778
    Consensus CDS
    CCDS45865.1
    UniProtKB/Swiss-Prot
    B2R4H3, B4E3C2, B5ME31, J3QL51, P18621, Q3KQW2, Q6NZ54, Q7M4M5
    UniProtKB/TrEMBL
    J3KRX5
    Related
    ENSP00000482577.1, ENST00000618619.4
    Conserved Domains (1) summary
    PTZ00178
    Location:1 → 165
    PTZ00178; 60S ribosomal protein L17; Provisional

  11. NM_001369557.1 → NP_001356486.1  large ribosomal subunit protein uL22 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC100778
    Consensus CDS
    CCDS45865.1
    UniProtKB/Swiss-Prot
    B2R4H3, B4E3C2, B5ME31, J3QL51, P18621, Q3KQW2, Q6NZ54, Q7M4M5
    UniProtKB/TrEMBL
    J3KRX5
    Conserved Domains (1) summary
    PTZ00178
    Location:1 → 165
    PTZ00178; 60S ribosomal protein L17; Provisional

  12. NM_001369558.1 → NP_001356487.1  large ribosomal subunit protein uL22 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC100778
    Consensus CDS
    CCDS45865.1
    UniProtKB/Swiss-Prot
    B2R4H3, B4E3C2, B5ME31, J3QL51, P18621, Q3KQW2, Q6NZ54, Q7M4M5
    UniProtKB/TrEMBL
    J3KRX5
    Conserved Domains (1) summary
    PTZ00178
    Location:1 → 165
    PTZ00178; 60S ribosomal protein L17; Provisional

  13. NM_001369560.1 → NP_001356489.1  large ribosomal subunit protein uL22 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC100778
    Consensus CDS
    CCDS92461.1
    UniProtKB/TrEMBL
    J3KRX5, J3QLC8
    Related
    ENSP00000463490.1, ENST00000580210.5
    Conserved Domains (1) summary
    PTZ00178
    Location:4 → 155
    PTZ00178; 60S ribosomal protein L17; Provisional

  14. NM_001369561.1 → NP_001356490.1  large ribosomal subunit protein uL22 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC100778
    Consensus CDS
    CCDS92461.1
    UniProtKB/TrEMBL
    J3KRX5, J3QLC8
    Conserved Domains (1) summary
    PTZ00178
    Location:4 → 155
    PTZ00178; 60S ribosomal protein L17; Provisional

  15. NM_001369562.1 → NP_001356491.1  large ribosomal subunit protein uL22 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC100778
    Consensus CDS
    CCDS56070.1
    Conserved Domains (1) summary
    PTZ00178
    Location:1 → 127
    PTZ00178; 60S ribosomal protein L17; Provisional

  16. NM_001369563.1 → NP_001356492.1  large ribosomal subunit protein uL22 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC100778
    Consensus CDS
    CCDS56070.1
    Related
    ENST00000584364.5
    Conserved Domains (1) summary
    PTZ00178
    Location:1 → 127
    PTZ00178; 60S ribosomal protein L17; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    49488481..49492465 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    49686222..49690206 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18621.3 GenPept UniProtKB/Swiss-Prot:P18621

Gene LinkOut

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