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Dusp12 dual specificity phosphatase 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64014, updated on 2-Nov-2024

Summary

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Official Symbol
Dusp12provided by RGD
Official Full Name
dual specificity phosphatase 12provided by RGD
Primary source
RGD:68375
See related
EnsemblRapid:ENSRNOG00000003100 AllianceGenome:RGD:68375
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
GKAP
Summary
Enables kinase binding activity and phosphoprotein phosphatase activity. Involved in positive regulation of glucokinase activity and protein dephosphorylation. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Orthologous to human DUSP12 (dual specificity phosphatase 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 47.3), Adrenal (RPKM 45.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dusp12 in Genome Data Viewer
Location:
13q24
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (85654914..85666431, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (83122192..83131800, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (89258309..89267402, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene ferritin light chain 1-like Neighboring gene DNA methyltransferase 3B, pseudogene 2 Neighboring gene uncharacterized LOC120096314 Neighboring gene Fc receptor-like B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. DUSP12 ameliorates myocardial ischemia-reperfusion injury through HSPB8-induced mitophagy. Cheng J, et al. J Biochem Mol Toxicol, 2023 May. PMID 36644958
  2. A novel cytosolic dual specificity phosphatase, interacting with glucokinase, increases glucose phosphorylation rate. Muñoz-Alonso MJ, et al. J Biol Chem, 2000 Oct 20. PMID 10913113
  3. Identification of the human YVH1 protein-tyrosine phosphatase orthologue reveals a novel zinc binding domain essential for in vivo function. Muda M, et al. J Biol Chem, 1999 Aug 20. PMID 10446167
  4. A growing family of dual specificity phosphatases with low molecular masses. Aoki N, et al. J Biochem, 2001 Jul. PMID 11432789
  5. The family-wide structure and function of human dual-specificity protein phosphatases. Jeong DG, et al. Acta Crystallogr D Biol Crystallogr, 2014 Feb. PMID 24531476

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DUSP12 ameliorates myocardial ischemia-reperfusion injury through HSPB8-induced mitophagy.
    Title: DUSP12 ameliorates myocardial ischemia-reperfusion injury through HSPB8-induced mitophagy.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine/serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of glucokinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
dual specificity protein phosphatase 12
Names
glucokinase-associated dual specificity phosphatase
NP_071584.1
XP_038946987.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022248.2 → NP_071584.1  dual specificity protein phosphatase 12

    See identical proteins and their annotated locations for NP_071584.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/Swiss-Prot
    Q9JIM4
    UniProtKB/TrEMBL
    A0A8I6AB94, A6IDQ3
    Related
    ENSRNOP00000004179.2, ENSRNOT00000004179.5
    Conserved Domains (1) summary
    cd00127
    Location:26 → 165
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    85654914..85666431 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039091059.2 → XP_038946987.1  dual specificity protein phosphatase 12 isoform X1

    UniProtKB/TrEMBL
    A6IDQ4
    Conserved Domains (1) summary
    cd14520
    Location:28 → 172
    DSP_DUSP12; dual specificity phosphatase domain of dual specificity protein phosphatase 12 and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JIM4.1 GenPept UniProtKB/Swiss-Prot:Q9JIM4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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