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SELL selectin L [ Homo sapiens (human) ]

Gene ID: 6402, updated on 4-Jan-2025

Summary

Official Symbol
SELLprovided by HGNC
Official Full Name
selectin Lprovided by HGNC
Primary source
HGNC:HGNC:10720
See related
Ensembl:ENSG00000188404 MIM:153240; AllianceGenome:HGNC:10720
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TQ1; LAM1; LEU8; LNHR; LSEL; CD62L; LYAM1; PLNHR; LECAM1
Summary
This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]
Expression
Biased expression in lymph node (RPKM 120.3), spleen (RPKM 87.6) and 5 other tissues See more
Orthologs
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Genomic context

See SELL in Genome Data Viewer
Location:
1q24.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (169690667..169711620, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (169046455..169067407, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (169659808..169680761, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2075 Neighboring gene selectin P Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2076 Neighboring gene uncharacterized LOC107985745 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:169636965-169637470 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2077 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2078 Neighboring gene selectin E Neighboring gene uncharacterized LOC101928628

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis.
EBI GWAS Catalog
Two new susceptibility loci 1q24.2 and 11p11.2 confer risk to severe acne.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env L-selectin downregulation induced by HIV-1 gp120 is completely reversed by AMD3100 (a CXCR4 antagonist), but not SDF-1 alpha PubMed
env CD4 ligation by HIV-1 gp120 induces metalloproteinase-dependent L-selectin downregulation in primary resting CD4+ T cells PubMed
Nef nef HIV-1 Nef mutants L37Q, 62EEEE/AAAA65, P72A/P75A, P78L, and F191A partially impair to downregulate CD62L in Jurkat cells PubMed
nef Both HIV-1 Nef and Vpu downregulate the cell surface expression of selectin L (CD62L) PubMed
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of selectin L (SELL) in primary human brain microvascular endothelial cells PubMed
Vpu vpu HIV-1 Vpu inhibits the transport of newly synthesized CD62L molecules toward the cell surface of Jurkat cells PubMed
vpu Both HIV-1 Nef and Vpu downregulate the cell surface expression of selectin L (CD62L) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding PubMed 
enables carbohydrate binding PubMed 
enables glycosphingolipid binding PubMed 
enables heparin binding PubMed 
enables oligosaccharide binding  
enables oligosaccharide binding PubMed 
enables protease binding PubMed 
enables protein binding PubMed 
enables sialic acid binding  
Component Evidence Code Pubs
is_active_in external side of plasma membrane  
is_active_in extracellular space  
located_in plasma membrane PubMed 
located_in plasma membrane  
located_in secretory granule membrane  

General protein information

Preferred Names
L-selectin
Names
CD62 antigen-like family member L
gp90-MEL
leukocyte surface antigen Leu-8
leukocyte-endothelial cell adhesion molecule 1
lymph node homing receptor
lymphocyte adhesion molecule 1
pln homing receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016132.1 RefSeqGene

    Range
    5083..26036
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000655.5NP_000646.3  L-selectin precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    AJ246000, BP393094, BQ004720, DA671852
    Consensus CDS
    CCDS53427.2
    UniProtKB/Swiss-Prot
    A0A024R8Z0, B2R6Q8, P14151, P15023, Q9UJ43
    UniProtKB/TrEMBL
    Q8WW79
    Related
    ENSP00000236147.5, ENST00000236147.6
    Conserved Domains (3) summary
    cd00033
    Location:197255
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd03592
    Location:39157
    CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)
    cd00054
    Location:165192
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RNA

  1. NR_029467.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two alternate 5' exons and has a distinct 5' end compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK298705, AL021940, BC020758, BP393094, CB164568, DC378123

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    169690667..169711620 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    169046455..169067407 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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