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atp1a1b ATPase Na+/K+ transporting subunit alpha 1b [ Danio rerio (zebrafish) ]

Gene ID: 64616, updated on 28-Oct-2024

Summary

Official Symbol
atp1a1bprovided by ZNC
Official Full Name
ATPase Na+/K+ transporting subunit alpha 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-001212-5
See related
Ensembl:ENSDARG00000019856 AllianceGenome:ZFIN:ZDB-GENE-001212-5
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb707; atp1a1l5; atp[a]1B2; zgc:92351; wu:fj34g01
Summary
Predicted to enable P-type sodium:potassium-exchanging transporter activity. Predicted to be involved in intracellular monoatomic cation homeostasis and monoatomic cation transmembrane transport. Predicted to act upstream of or within potassium ion transport and sodium ion transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in central nervous system and neural tube. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2DD. Orthologous to human ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
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Genomic context

See atp1a1b in Genome Data Viewer
Location:
chromosome: 9
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (35901663..35922188)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (36092478..36113003)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 28 Neighboring gene mab-21-like 3 Neighboring gene uncharacterized LOC137496487 Neighboring gene low density lipoprotein receptor-related protein 1Bb

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Clone Names

  • MGC92351

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables P-type potassium transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables P-type sodium:potassium-exchanging transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in intracellular potassium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular sodium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in proton transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sodium ion export across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sodium/potassium-transporting ATPase subunit alpha-1b
Names
ATPase, Na+/K+ transporting, alpha 1 polypeptide like 5
ATPase, Na+/K+ transporting, alpha 1b polypeptide
NP_571765.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131690.1NP_571765.1  sodium/potassium-transporting ATPase subunit alpha-1b

    See identical proteins and their annotated locations for NP_571765.1

    Status: PROVISIONAL

    Source sequence(s)
    AY008375
    UniProtKB/TrEMBL
    Q9DEU1
    Related
    ENSDARP00000021569.5, ENSDART00000005086.6
    Conserved Domains (6) summary
    smart00831
    Location:41115
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    COG4087
    Location:608754
    COG4087; Soluble P-type ATPase [General function prediction only]
    TIGR01106
    Location:321025
    ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit
    pfam00122
    Location:135366
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:8011010
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam13246
    Location:428523
    Cation_ATPase; Cation transport ATPase (P-type)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    35901663..35922188
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394761.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    259033..279558
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)