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hsd17b8 hydroxysteroid (17-beta) dehydrogenase 8 [ Danio rerio (zebrafish) ]

Gene ID: 64815, updated on 12-Sep-2024

Summary

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Official Symbol
hsd17b8provided by ZNC
Official Full Name
hydroxysteroid (17-beta) dehydrogenase 8provided by ZNC
Primary source
ZFIN:ZDB-GENE-010110-1
See related
Ensembl:ENSDARG00000001169 AllianceGenome:ZFIN:ZDB-GENE-010110-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
KE6; fabgl; zgc:112550; si:dz12f11.4
Summary
Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor and quinone binding activity. Predicted to be involved in fatty acid biosynthetic process. Orthologous to human HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See hsd17b8 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (7173871..7179691)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (7254946..7260766)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene transporter associated with antigen processing, subunit type a Neighboring gene bromodomain containing 2a Neighboring gene collagen, type XI, alpha 2 Neighboring gene retinoid x receptor, beta a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Waterborne fluoride exposure changed the structure and the expressions of steroidogenic-related genes in gonads of adult zebrafish (Danio rerio). Li M, et al. Chemosphere, 2016 Feb. PMID 26692514
  2. Identification of seven genes in the major histocompatibility complex class I region of the zebrafish. Sültmann H, et al. Scand J Immunol, 2000 Jun. PMID 10849368
  3. Beta-Hydroxysteroid Dehydrogenase Genes in Orange-Spotted Grouper (Epinephelus coioides): Genome-Wide Identification and Expression Analysis During Sex Reversal. Xiao L, et al. Front Genet, 2020. PMID 32194632, Free PMC Article
  4. Alternative haplotypes of antigen processing genes in zebrafish diverged early in vertebrate evolution. McConnell SC, et al. Proc Natl Acad Sci U S A, 2016 Aug 23. PMID 27493218, Free PMC Article
  5. Toxicogenomic and phenotypic analyses of bisphenol-A early-life exposure toxicity in zebrafish. Lam SH, et al. PLoS One, 2011. PMID 22194820, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
(3R)-3-hydroxyacyl-CoA dehydrogenase
Names
FabG (beta-ketoacyl-[acyl-carrier-protein] reductase, E. coli) like
NP_001005292.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005292.2 → NP_001005292.2  (3R)-3-hydroxyacyl-CoA dehydrogenase

    See identical proteins and their annotated locations for NP_001005292.2

    Status: PROVISIONAL

    Source sequence(s)
    BC093373
    UniProtKB/TrEMBL
    Q561S1
    Related
    ENSDARP00000001459.9, ENSDART00000001331.10
    Conserved Domains (2) summary
    cd05333
    Location:10 → 254
    BKR_SDR_c; beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs
    PRK05653
    Location:13 → 254
    fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    7173871..7179691
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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