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MRPS11 mitochondrial ribosomal protein S11 [ Homo sapiens (human) ]

Gene ID: 64963, updated on 2-Nov-2024

Summary

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Official Symbol
MRPS11provided by HGNC
Official Full Name
mitochondrial ribosomal protein S11provided by HGNC
Primary source
HGNC:HGNC:14050
See related
Ensembl:ENSG00000181991 MIM:611977; AllianceGenome:HGNC:14050
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HCC-2; S11mt; uS11m; MRP-S11
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that contains a high level of sequence similarity with ribosomal protein S11P family members. A pseudogene corresponding to this gene is found on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]
Expression
Ubiquitous expression in thyroid (RPKM 4.3), brain (RPKM 3.6) and 25 other tissues See more
Orthologs
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Genomic context

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See MRPS11 in Genome Data Viewer
Location:
15q25.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (88467708..88480776)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (86222020..86235375)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (89010939..89024007)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370959 Neighboring gene VISTA enhancer hs2510 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10026 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:89008954-89010153 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10027 Neighboring gene mitochondrial ribosomal protein L46 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:89027733-89028522 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:89031074-89031591 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:89031592-89032108 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:89034431-89034930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:89039910-89040410 Neighboring gene NANOG hESC enhancer GRCh37_chr15:89045662-89046192 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:89047351-89048125 Neighboring gene DET1 partner of COP1 E3 ubiquitin ligase Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:89081925-89082504 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:89084239-89084817 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:89084818-89085395 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:89085416-89085617 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6789 Neighboring gene uncharacterized LOC124903547 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:89090642-89091516 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:89104975-89105595 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:89111661-89112160 Neighboring gene long intergenic non-protein coding RNA 1586 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:89147601-89148307 Neighboring gene apoptosis enhancing nuclease

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Meta-analysis of differentially expressed genes in ankylosing spondylitis. Lee YH, et al. Genet Mol Res, 2015 May 18. PMID 26125709
  2. ZNF143 activates gene expression in response to DNA damage and binds to cisplatin-modified DNA. Ishiguchi H, et al. Int J Cancer, 2004 Oct 10. PMID 15300802
  3. MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome. Cámara Y, et al. Cell Metab, 2011 May 4. PMID 21531335
  4. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. Kenmochi N, et al. Genomics, 2001 Sep. PMID 11543634
  5. Ribosome. The structure of the human mitochondrial ribosome. Amunts A, et al. Science, 2015 Apr 3. PMID 25838379, Free PMC Article

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The downregulated gene with the largest effect size in ankylosing spondylitis was mitochondrial ribosomal protein S11 (MRPS11). (Meta-analysis)
    Title: Meta-analysis of differentially expressed genes in ankylosing spondylitis.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ22512, FLJ23406

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial translation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
  
part_of mitochondrial small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial small ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mitochondrial small ribosomal subunit ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of mitochondrial small ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion HTP PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
small ribosomal subunit protein uS11m
Names
28S ribosomal protein S11, mitochondrial
cervical cancer proto-oncogene 2 protein
mitochondrial small ribosomal subunit protein uS11m

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321970.2 → NP_001308899.1  small ribosomal subunit protein uS11m isoform c

    Status: REVIEWED

    Source sequence(s)
    AC013489, BC012489
    UniProtKB/TrEMBL
    Q53FX9, Q53GJ8
    Conserved Domains (2) summary
    cl00332
    Location:84 → 192
    Ribosomal_S11; Ribosomal protein S11
    cl26081
    Location:29 → 103
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase

  2. NM_001321972.2 → NP_001308901.1  small ribosomal subunit protein uS11m isoform d

    Status: REVIEWED

    Source sequence(s)
    AC013489, AC142401
    UniProtKB/Swiss-Prot
    P82912
    Conserved Domains (1) summary
    cl00332
    Location:50 → 158
    Ribosomal_S11; Ribosomal protein S11

  3. NM_001321973.2 → NP_001308902.1  small ribosomal subunit protein uS11m isoform e

    Status: REVIEWED

    Source sequence(s)
    AB049944, AC013489, BM966864, CD172722
    UniProtKB/Swiss-Prot
    P82912

  4. NM_001321974.2 → NP_001308903.1  small ribosomal subunit protein uS11m isoform f

    Status: REVIEWED

    Source sequence(s)
    AB049944, AC013489, CD172722
    UniProtKB/Swiss-Prot
    P82912
    Related
    ENST00000560850.1

  5. NM_001321976.2 → NP_001308905.1  small ribosomal subunit protein uS11m isoform g

    Status: REVIEWED

    Source sequence(s)
    AC013489, AC142401, CD172722
    UniProtKB/Swiss-Prot
    P82912

  6. NM_022839.5 → NP_073750.2  small ribosomal subunit protein uS11m isoform a

    See identical proteins and their annotated locations for NP_073750.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the predominant variant and it encodes isoform a.
    Source sequence(s)
    AB049944, AC013489
    Consensus CDS
    CCDS10342.1
    UniProtKB/Swiss-Prot
    B2RD52, P82912, Q969D7, Q96GI3, Q9BYC3
    UniProtKB/TrEMBL
    Q53FX9, Q53GJ8
    Related
    ENSP00000317376.4, ENST00000325844.9
    Conserved Domains (2) summary
    PRK02812
    Location:30 → 104
    PRK02812; ribose-phosphate pyrophosphokinase; Provisional
    cl00332
    Location:85 → 193
    Ribosomal_S11; Ribosomal protein S11

  7. NM_176805.4 → NP_789775.1  small ribosomal subunit protein uS11m isoform b

    See identical proteins and their annotated locations for NP_789775.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame internal segment of coding sequence, compared to variant 1, which causes the predicted protein (isoform b) to be shorter than isoform a. The predicted ORF of this rare transcript has not been experimentally confirmed.
    Source sequence(s)
    AB049944, AC013489, BC009451
    Consensus CDS
    CCDS10343.1
    UniProtKB/TrEMBL
    Q53FX9, Q53GJ8
    Related
    ENSP00000318054.7, ENST00000353598.6
    Conserved Domains (1) summary
    cl00332
    Location:74 → 160
    Ribosomal_S11; Ribosomal protein S11

RNA

  1. NR_135915.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC013489, DA803430

  2. NR_135917.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AB049944, AC013489, AC142401

  3. NR_135918.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AB049944, AC013489, AC142401, BE621879

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    88467708..88480776
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    86222020..86235375
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054378652.1 → XP_054234627.1  small ribosomal subunit protein uS11m isoform X1

    UniProtKB/Swiss-Prot
    B2RD52, P82912, Q969D7, Q96GI3, Q9BYC3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P82912.2 GenPept UniProtKB/Swiss-Prot:P82912

Gene LinkOut

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