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Slc16a8 solute carrier family 16 member 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 65200, updated on 2-Nov-2024

Summary

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Official Symbol
Slc16a8provided by RGD
Official Full Name
solute carrier family 16 member 8provided by RGD
Primary source
RGD:69282
See related
EnsemblRapid:ENSRNOG00000012090 AllianceGenome:RGD:69282
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mct3
Summary
Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in lactate transmembrane transport. Located in basal plasma membrane. Orthologous to human SLC16A8 (solute carrier family 16 member 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Uterus (RPKM 4.5), Brain (RPKM 3.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc16a8 in Genome Data Viewer
Location:
7q34
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (112698701..112702496, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (110818274..110822069, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (120486266..120490192, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093688 Neighboring gene uncharacterized LOC134479937 Neighboring gene protein interacting with PRKCA 1 Neighboring gene BAR/IMD domain containing adaptor protein 2 like 2 Neighboring gene phospholipase A2 group VI

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Monocarboxylate transporter MCT1 is located in the apical membrane and MCT3 in the basal membrane of rat RPE. Philp NJ, et al. Am J Physiol, 1998 Jun. PMID 9841555
  2. Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70). Wilson MC, et al. J Biol Chem, 2005 Jul 22. PMID 15917240
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables monocarboxylic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables secondary active monocarboxylate transmembrane transporter activity TAS
Traceable Author Statement
more info
 PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lactate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basal plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
monocarboxylate transporter 3
Names
solute carrier family 16 (monocarboxylate transporter), member 8
solute carrier family 16 (monocarboxylic acid transporters), member 8
solute carrier family 16, member 8 (monocarboxylic acid transporter 3)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031744.2 → NP_113932.2  monocarboxylate transporter 3

    See identical proteins and their annotated locations for NP_113932.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    G3V7K8, O70461
    Related
    ENSRNOP00000016248.1, ENSRNOT00000016247.5
    Conserved Domains (1) summary
    TIGR00892
    Location:14 → 440
    2A0113; monocarboxylate transporter 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    112698701..112702496 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017595102.2 → XP_017450591.2  monocarboxylate transporter 3 isoform X1

    UniProtKB/Swiss-Prot
    G3V7K8, O70461
    Conserved Domains (1) summary
    TIGR00892
    Location:14 → 440
    2A0113; monocarboxylate transporter 1

  2. XM_063264226.1 → XP_063120296.1  monocarboxylate transporter 3 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70461.2 GenPept UniProtKB/Swiss-Prot:O70461

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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